Microbial exposure during early human development primes fetal immune cells
Sign Up to like & getrecommendations! Published in 2021 at "Cell"
DOI: 10.1016/j.cell.2021.04.039
Abstract: Summary The human fetal immune system begins to develop early during gestation; however, factors responsible for fetal immune-priming remain elusive. We explored potential exposure to microbial agents in utero and their contribution toward activation of… read more here.
Keywords: exposure; early human; exposure early; fetal immune ... See more keywords
Microbial Exposure Enhances Immunity to Pathogens Recognized by TLR2 but Increases Susceptibility to Cytokine Storm through TLR4 Sensitization.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.07.028
Abstract: Microbial exposures can define an individual's basal immune state. Cohousing specific pathogen-free (SPF) mice with pet store mice, which harbor numerous infectious microbes, results in global changes to the immune system, including increased circulating phagocytes and… read more here.
Keywords: response; tlr2; cytokine storm; mice ... See more keywords
Early microbial exposure shapes adult immunity by altering CD8+ T cell development
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2212548119
Abstract: Significance Microbial exposure in early life can have long-term consequences on health. However, our understanding of how the microbial environment shapes the offspring’s immune system is incomplete. In this report, we found that the proportion… read more here.
Keywords: adult immunity; microbial exposure; early microbial; exposure ... See more keywords
Recent Anti-Microbial Exposure Is Associated with More Complications after Elective Surgery.
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DOI: 10.1089/sur.2018.031
Abstract: BACKGROUND Recent anti-microbial exposure has been associated with poor outcomes after infection in a mixed population. We hypothesized that recent anti-microbial exposure would be associated with poor outcomes of elective surgery. METHODS From August 2015… read more here.
Keywords: recent anti; surgery; infection; anti microbial ... See more keywords
Twenty Important Research Questions in Microbial Exposure and Social Equity
Sign Up to like & getrecommendations! Published in 2022 at "mSystems"
DOI: 10.1128/msystems.01240-21
Abstract: Social and political policy, human activities, and environmental change affect the ways in which microbial communities assemble and interact with people. These factors determine how different social groups are exposed to beneficial and/or harmful microorganisms,… read more here.
Keywords: exposure social; microbial exposure; social equity; policy ... See more keywords