Gut Microbial β-Glucuronidase Inhibition via Catalytic Cycle Interception
Sign Up to like & getrecommendations! Published in 2018 at "ACS Central Science"
DOI: 10.1021/acscentsci.8b00239
Abstract: Microbial β-glucuronidases (GUSs) cause severe gut toxicities that limit the efficacy of cancer drugs and other therapeutics. Selective inhibitors of bacterial GUS have been shown to alleviate these side effects. Using structural and chemical biology,… read more here.
Keywords: via catalytic; inhibition; glucuronidase inhibition; microbial glucuronidase ... See more keywords
The Role of Gut Microbial β-Glucuronidase in Estrogen Reactivation and Breast Cancer
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.631552
Abstract: Over the past decade, the gut microbiota has received considerable attention for its interactions with the host. Microbial β-glucuronidase generated by this community has hence aroused concern for its biotransformation activity to a wide range… read more here.
Keywords: microbial glucuronidase; glucuronidase; biology; breast cancer ... See more keywords