The gut microbial metabolite phenylacetylglycine protects against cardiac injury caused by ischemia/reperfusion through activating β2AR.
Sign Up to like & getrecommendations! Published in 2020 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2020.108720
Abstract: BACKGROUND Myocardial ischemia/reperfusion (I/R) injury is closely related to cardiomyocyte apoptosis. Stimulating β2 adrenergic receptor (β2AR) can effectively combat cardiomyocyte apoptosis. Previous studies demonstrate that the gut microbial metabolite phenylacetylglycine (PAGly) can stimulate β2AR. However,… read more here.
Keywords: apoptosis; gut microbial; ischemia reperfusion; microbial metabolite ... See more keywords
Microbial Metabolite Signaling Is Required for Systemic Iron Homeostasis.
Sign Up to like & getrecommendations! Published in 2019 at "Cell metabolism"
DOI: 10.1016/j.cmet.2019.10.005
Abstract: Iron is a central micronutrient needed by all living organisms. Competition for iron in the intestinal tract is essential for the maintenance of indigenous microbial populations and for host health. How symbiotic relationships between hosts… read more here.
Keywords: iron homeostasis; microbial metabolite; metabolite signaling; systemic iron ... See more keywords
Microbial metabolite as icebreaker for immunotherapy.
Sign Up to like & getrecommendations! Published in 2022 at "Cell metabolism"
DOI: 10.1016/j.cmet.2022.03.003
Abstract: Immunotherapy has limited success in triple-negative breast cancer (TNBC). In this issue of Cell Metabolism, Wang et al. found that microbial metabolite TMAO boosts CD8+ T cell-mediated antitumor immunity by inducing pyroptosis in tumor cells, enhancing the… read more here.
Keywords: immunotherapy; icebreaker immunotherapy; cell; microbial metabolite ... See more keywords
Metabolic programming of the epigenome: host and gut microbial metabolite interactions with host chromatin
Sign Up to like & getrecommendations! Published in 2017 at "Translational Research"
DOI: 10.1016/j.trsl.2017.08.005
Abstract: &NA; The mammalian gut microbiota has been linked to host developmental, immunologic, and metabolic outcomes. This collection of trillions of microbes inhabits the gut and produces a myriad of metabolites, which are measurable in host… read more here.
Keywords: gut; metabolic programming; host; microbial metabolite ... See more keywords
Targeting the Aryl Hydrocarbon Receptor with Microbial Metabolite Mimics Alleviates Experimental Colitis in Mice.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00208
Abstract: Targeting the aryl hydrocarbon receptor (AhR) is an emerging therapeutic strategy for multiple diseases (e.g., inflammatory bowel disease). Thermosporothrix hazakensis microbial metabolite 2-(1'H-indole-3'-carbonyl)-thiazole-4-carboxylic acid methyl ester (ITE) is a putative AhR endogenous ligand. To improve… read more here.
Keywords: hydrocarbon receptor; microbial metabolite; targeting aryl; aryl hydrocarbon ... See more keywords
Mining the microbiota for microbial and metabolite-based immunotherapies
Sign Up to like & getrecommendations! Published in 2019 at "Nature Reviews Immunology"
DOI: 10.1038/s41577-019-0144-5
Abstract: Trillions of microorganisms transit through and reside in the mammalian gastrointestinal tract each day, collectively producing thousands of small molecules and metabolites with local and systemic effects on host physiology. Identifying effector microorganisms that causally… read more here.
Keywords: physiology; based immunotherapies; metabolite based; mining microbiota ... See more keywords
The microbial metabolite trimethylamine-N-oxide in association with inflammation and microbial dysregulation in three HIV cohorts at various disease stages
Sign Up to like & getrecommendations! Published in 2018 at "AIDS"
DOI: 10.1097/qad.0000000000001813
Abstract: Objective: HIV-1-infection infers an increased cardiovascular risk where gut dysbiosis and microbial translocation may contribute. We assessed TMAO, a microbial metabolite with atherosclerotic properties, in plasma of HIV-1-infected individuals at different clinical stages in relation… read more here.
Keywords: infected individuals; hiv; inflammation; tmao levels ... See more keywords
Microbial metabolite deoxycholic acid promotes vasculogenic mimicry formation in intestinal carcinogenesis.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer science"
DOI: 10.1111/cas.15208
Abstract: High-fat diet (HFD) leads to long-term exposure to gut microbial metabolite secondary bile acids such as deoxycholic acid (DCA) in the intestine, which is closely linked to colorectal cancer (CRC). Evidence reveals that vasculogenic mimicry… read more here.
Keywords: microbial metabolite; intestinal carcinogenesis; emt; formation ... See more keywords
Microbial metabolite protects against infection
Sign Up to like & getrecommendations! Published in 2020 at "Science Signaling"
DOI: 10.1126/scisignal.abe9388
Abstract: Commensal-derived d-lactate promotes pathogen capture and clearance by Kupffer cells in the liver. Commensal-derived d-lactate promotes pathogen capture and clearance by Kupffer cells in the liver. read more here.
Keywords: microbial metabolite; metabolite protects; protects infection;
Placental microbial–metabolite profiles and inflammatory mechanisms associated with preterm birth
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Pathology"
DOI: 10.1136/jclinpath-2020-206536
Abstract: There is growing emphasis on the potential significance of the placental microbiome and microbiome–metabolite interactions in immune responses and subsequent pregnancy outcome, especially in relation to preterm birth (PTB). This review discusses in detail the… read more here.
Keywords: preterm birth; microbial metabolite; placental microbiome; placental microbial ... See more keywords
Microbial metabolite butyrate promotes induction of IL-10+IgM+ plasma cells
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DOI: 10.1371/journal.pone.0266071
Abstract: The microbially-derived short-chain fatty acid butyrate is a central inhibitor of inflammatory innate and adaptive immune responses. Emerging evidence suggests that butyrate induces differentiation of IL-10-producing (IL-10+) regulatory B cells. However, the underlying mechanisms of… read more here.
Keywords: metabolite butyrate; plasma cells; butyrate; microbial metabolite ... See more keywords