Mining Microbial Signals for Enhanced Biodiscovery of Secondary Metabolites.
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DOI: 10.1007/978-1-4939-6691-2_19
Abstract: The advent of metagenomics based biodiscovery has provided researchers with previously unforeseen access to the rich tapestry of natural bioactivity that exists in the biosphere. Unhindered by the "culturable bottleneck" that has severely limited the… read more here.
Keywords: biodiscovery; enhanced biodiscovery; biodiscovery secondary; signals enhanced ... See more keywords
Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host
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DOI: 10.1038/s41586-018-0125-z
Abstract: Somatic mutations in tet methylcytosinedioxygenase 2 (TET2), which encodes an epigenetic modifier enzyme, drive the development of haematopoietic malignancies1–7. In both humans and mice, TET2 deficiency leads to increased self-renewal of haematopoietic stem cells with… read more here.
Keywords: pre leukaemic; tet2; pmp; microbial signals ... See more keywords
Microbial signals in primary and metastatic brain tumors
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DOI: 10.1038/s41591-025-03957-4
Abstract: Gliomas and brain metastases are associated with poor prognosis, necessitating a deeper understanding of brain tumor biology and the development of effective therapeutic strategies. Although our group and others have demonstrated microbial presence in various… read more here.
Keywords: brain; brain metastases; microbial signals; signals primary ... See more keywords