Tonsillar Microbiome‐Derived Lantibiotics Induce Structural Changes of IL‐6 and IL‐21 Receptors and Modulate Host Immunity
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202202706
Abstract: Emerging evidence emphasizes the functional impacts of host microbiome on the etiopathogenesis of autoimmune diseases, including rheumatoid arthritis (RA). However, there are limited mechanistic insights into the contribution of microbial biomolecules especially microbial peptides toward… read more here.
Keywords: induce structural; microbiome derived; derived lantibiotics; tonsillar microbiome ... See more keywords
The microbiome-derived metabolite trimethylamine N-oxide is associated with chronic kidney disease risk
Sign Up to like & getrecommendations! Published in 2025 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-025-13481-7
Abstract: Previous studies have established a correlation between the microbiome-derived metabolite trimethylamine N-oxide (TMAO) and decreased renal function, but with great heterogeneity. Moreover, population-based evidence remains scarce, particularly in Chinese populations. We designed a meta-analysis and… read more here.
Keywords: ckd; derived metabolite; trimethylamine oxide; risk ... See more keywords
The influence of acute and chronic coronary syndrome on the gut microbiome and downstream microbiome-derived metabolites—Microbiome in acute myocardial infarction—MIAMI-Trial
Sign Up to like & getrecommendations! Published in 2025 at "Basic Research in Cardiology"
DOI: 10.1007/s00395-025-01134-9
Abstract: Cardiovascular diseases (CVD) are the leading cause of morbidity and mortality in the industrialized world. The gut microbiome influences CVD, through atherogenic metabolites like trimethylamine N-oxide (TMAO) or protective effects through short-chain fatty acids (SCFA)… read more here.
Keywords: microbiome; coronary syndrome; gut microbiome; derived metabolites ... See more keywords
A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis.
Sign Up to like & getrecommendations! Published in 2020 at "Cell metabolism"
DOI: 10.1016/j.cmet.2020.06.005
Abstract: Dysregulation of the gut microbiome has been implicated in the progression of non-alcoholic fatty liver disease (NAFLD) to advanced fibrosis and cirrhosis. To determine the diagnostic capacity of this association, we compared stool microbiomes across… read more here.
Keywords: derived signature; cirrhosis; universal gut; microbiome derived ... See more keywords
A Validated, Fast Method for Quantification of Sterols and Gut Microbiome Derived 5α/β-Stanols in Human Feces by Isotope Dilution LC-High-Resolution MS.
Sign Up to like & getrecommendations! Published in 2018 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.8b01278
Abstract: There has been an increasing interest during recent years in the role of the gut microbiome on health and disease. Therefore, metabolites in human feces related to microbial activity are attractive surrogate marker to track… read more here.
Keywords: high resolution; method quantification; human feces; microbiome derived ... See more keywords
Microbiome-derived metabolite effects on intestinal barrier integrity and immune cell response to infection
Sign Up to like & getrecommendations! Published in 2024 at "Microbiology"
DOI: 10.1101/2024.02.06.579072
Abstract: The gut microbiota exerts a significant influence on human health and disease. While compositional changes in the gut microbiota in specific diseases can easily be determined, we lack a detailed mechanistic understanding of how these… read more here.
Keywords: metabolite effects; physiology; response infection; intestinal barrier ... See more keywords
Microbiome-derived carnitine mimics as previously unknown mediators of gut-brain axis communication
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.aax6328
Abstract: Discovery of novel bacterial metabolites reveals an unprecedented role for the microbiome in gut-brain axis communication. Alterations to the gut microbiome are associated with various neurological diseases, yet evidence of causality and identity of microbiome-derived… read more here.
Keywords: axis communication; brain axis; microbiome derived; brain ... See more keywords
Abstract 576: A novel intestinal microbiome-derived peptide modulates host T cell activation
Sign Up to like & getrecommendations! Published in 2019 at "Immunology"
DOI: 10.1158/1538-7445.am2019-576
Abstract: The microbiome shapes the metabolic and immunological landscape of individuals in health and disease and represents a new robust source of bioactive molecules with therapeutic potential. Second Genome’s large and curated microbiome database coupled with… read more here.
Keywords: activation; novel intestinal; microbiome derived; cell ... See more keywords
Facilitation of Gastrointestinal (GI) Tract Microbiome-Derived Lipopolysaccharide (LPS) Entry Into Human Neurons by Amyloid Beta-42 (Aβ42) Peptide
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2019.00545
Abstract: Human gastrointestinal (GI)-tract microbiome-derived lipopolysaccharide (LPS): (i) has been recently shown to target, accumulate within, and eventually encapsulate neuronal nuclei of the human central nervous system (CNS) in Alzheimer’s disease (AD) brain; and (ii) this… read more here.
Keywords: gastrointestinal tract; neuronal nuclei; derived lipopolysaccharide; lipopolysaccharide lps ... See more keywords
Microbiome-Derived Lipopolysaccharide (LPS) Selectively Inhibits Neurofilament Light Chain (NF-L) Gene Expression in Human Neuronal-Glial (HNG) Cells in Primary Culture
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2018.00896
Abstract: The remarkable co-localization of highly pro-inflammatory lipopolysaccharide (LPS) with sporadic Alzheimer’s disease (AD)-affected neuronal nuclei suggests that there may be some novel pathogenic contribution of this heat stable neurotoxin to neuronal activity and neuron-specific gene… read more here.
Keywords: hng cells; lipopolysaccharide lps; expression; microbiome derived ... See more keywords
Microbiome-Derived Trimethylamine N-Oxide (TMAO) as a Multifaceted Biomarker in Cardiovascular Disease: Challenges and Opportunities
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms252312511
Abstract: Biomarkers play a crucial role in various stages of disease management, including screening, diagnosis, prediction, prognosis, treatment, and safety monitoring. Although they are powerful tools in disease diagnosis, management, and drug development, identifying and validating… read more here.
Keywords: disease; trimethylamine oxide; microbiome derived; cardiovascular disease ... See more keywords