A Review of Gut Microbiota‐Derived Metabolites in Tumor Progression and Cancer Therapy
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202207366
Abstract: Gut microbiota‐derived metabolites are key hubs connecting the gut microbiome and cancer progression, primarily by remodeling the tumor microenvironment and regulating key signaling pathways in cancer cells and multiple immune cells. The use of microbial… read more here.
Keywords: microbial metabolites; gut microbiota; derived metabolites; cancer ... See more keywords
The regulatory roles of dietary fibers on host health via gut microbiota-derived short chain fatty acids.
Sign Up to like & getrecommendations! Published in 2021 at "Current opinion in pharmacology"
DOI: 10.1016/j.coph.2021.11.001
Abstract: As a component of nutraceuticals, dietary fibers (DFs) are essential for maintain human growth and health via the regulation of gut microbiota in the digestive tract. In this review, we summarize food-derived DFs and their… read more here.
Keywords: gut microbiota; microbiota derived; health via; dietary fibers ... See more keywords
Kiwifruit drives human microbiota-derived DNA to stimulate IL-7 secretion in intestinal epithelial cells
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2020.103882
Abstract: Abstract Intestinal immune tolerance is maintained through the interplay between commensal microbiota, immune cells and epithelium. Constitutive intestinal epithelial-secreted interleukin (IL)-7 facilitates the proliferation and thus maintenance of gamma-delta T lymphocytes, which preserves intestinal mucosal… read more here.
Keywords: secretion intestinal; intestinal epithelial; secretion; microbiota ... See more keywords
Microbiota-derived metabolites as diagnostic markers for respiratory fungal infections.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2020.113473
Abstract: An emerging body of evidence has highlighted the significant role of the pulmonary microbiota during respiratory infections. The individual microbiome is nowadays recognized to supervise the outcome of the host-pathogen interaction by orchestrating mechanisms of… read more here.
Keywords: respiratory fungal; metabolites diagnostic; diagnostic markers; microbiota derived ... See more keywords
Gut-microbiota-derived extracellular vesicles: Overlooked mediators in host-helminth interactions?
Sign Up to like & getrecommendations! Published in 2021 at "Trends in parasitology"
DOI: 10.1016/j.pt.2021.05.009
Abstract: Helminth infections impact the composition of the mammalian gut microbiota; however, the mechanisms underpinning these interactions are, thus far, unknown. In this article, we propose that microbiota-derived extracellular vesicles might represent key players in host-helminth-microbiome… read more here.
Keywords: extracellular vesicles; host helminth; microbiota; derived extracellular ... See more keywords
Gut Microbiota-Derived Metabolites and Cardiovascular Disease: Focus on Trimethylamine-N-oxide.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.5c08378
Abstract: Cardiovascular disease remains the leading cause of global morbidity and mortality, with growing evidence highlighting the role of gut microbiota-derived metabolites in its pathogenesis. Among these, trimethylamine-N-oxide (TMAO) has emerged as a key pro-atherogenic metabolite… read more here.
Keywords: gut microbiota; derived metabolites; gut; cardiovascular disease ... See more keywords
Implications of Gut Microbiota-Derived Metabolites in Neurological Disorders.
Sign Up to like & getrecommendations! Published in 2025 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.5c00414
Abstract: Neurological disorders (NDs) represent a significant global health challenges, with neurodegeneration being a common pathological feature. Recent investigations indicate the involvement of gut microbiota-derived metabolites in these disorders, such as neuroinflammation, oxidative stress, and cognitive… read more here.
Keywords: brain; gut microbiota; derived metabolites; neurological disorders ... See more keywords
A Nitrogen Metabolic Enzyme Provides Salmonella Fitness Advantage by Promoting Utilization of Microbiota-Derived Carbon Source.
Sign Up to like & getrecommendations! Published in 2021 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.0c00836
Abstract: Microbes support their growth in vertebrate hosts by exploiting a large variety of dietary components as nutrients, which determines the composition of gut microbiota. A pathogen Salmonella expands by utilizing 1,2-propanediol, a microbiota-fermented product, during… read more here.
Keywords: utilization; salmonella; derived carbon; carbon source ... See more keywords
Lugdunin amplifies innate immune responses in the skin in synergy with host- and microbiota-derived factors
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-10646-7
Abstract: Recently our groups discovered lugdunin, a new cyclic peptide antibiotic that inhibits Staphylococcus aureus epithelial colonization in humans and rodents. In this work, we analyzed its immuno-modulatory and antimicrobial potential as a single agent or… read more here.
Keywords: microbiota; derived factors; keratinocytes mouse; host ... See more keywords
Effect of the gut microbiota-derived tryptophan metabolite indole-3-acetic acid in pneumonia
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-63611-y
Abstract: Gut microbiota influence the severity of pneumonia by producing metabolites that enhance systemic and pulmonary immune responses. Preclinical studies suggested that gut microbiota-derived indoles have protective effects against numerous diseases, including influenza and abdominal infections.… read more here.
Keywords: indole acetic; pneumonia; gut microbiota; microbiota derived ... See more keywords
Gut microbiota-derived hexa-acylated lipopolysaccharides enhance cancer immunotherapy responses
Sign Up to like & getrecommendations! Published in 2025 at "Nature Microbiology"
DOI: 10.1038/s41564-025-01930-y
Abstract: The gut microbiome modulates immunotherapy treatment responses, and this may explain why immune checkpoint inhibitors, such as anti-PD-1, are only effective in some patients. Previous studies correlated lipopolysaccharide (LPS)-producing gut microbes with poorer prognosis; however,… read more here.
Keywords: hexa acylated; acylated lps; microbiota derived; immunotherapy responses ... See more keywords