Evidence of Cis/Trans-Isomerization at Pro7/Pro16 in the Lasso Peptide Microcin J25
Sign Up to like & getrecommendations! Published in 2019 at "Journal of The American Society for Mass Spectrometry"
DOI: 10.1007/s13361-019-02134-5
Abstract: AbstractMicrocin J25 is a ribosomal synthesized and post-translationally modified peptide (RiPP) characterized by a mechanically interlocked topology called the lasso fold. This structure provides microcin J25 a potent antimicrobial activity resulting from internalization via the… read more here.
Keywords: cis trans; microcin j25; j25; topology ... See more keywords
Structural mechanism of transcription inhibition by lasso peptides microcin J25 and capistruin
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1817352116
Abstract: Significance Many bacteria produce antimicrobial peptides for survival under stressful conditions. Some of these antimicrobial peptides are lasso peptides, which have a unique lasso-like topology and have generated great interest as a result of their… read more here.
Keywords: lasso peptides; inhibition; peptides microcin; rnap ... See more keywords
Bacteriocin-Based Synergetic Consortia: a Promising Strategy to Enhance Antimicrobial Activity and Broaden the Spectrum of Inhibition
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DOI: 10.1128/spectrum.00406-21
Abstract: Reuterin and bacteriocins, including microcin J25, pediocin PA-1, nisin were produced and purified with >90% purity. Using the broth-based checkerboard assay the interaction between these compounds (synergetic, additive, or antagonistic) was assessed. ABSTRACT Bacteria-derived natural… read more here.
Keywords: acid; reuterin; microcin j25; synergetic consortia ... See more keywords
Gastrointestinal Stability and Cytotoxicity of Bacteriocins From Gram-Positive and Gram-Negative Bacteria: A Comparative in vitro Study
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DOI: 10.3389/fmicb.2021.780355
Abstract: Bacteriocins are receiving increased attention as potent candidates in food preservation and medicine. Although the inhibitory activity of bacteriocins has been studied widely, little is known about their gastrointestinal stability and toxicity toward normal human… read more here.
Keywords: gastrointestinal stability; microcin j25; stability; pediocin bactofencin ... See more keywords
Impact of microcin J25 on the porcine microbiome in a continuous culture model
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DOI: 10.3389/fmicb.2022.930392
Abstract: The increased prevalence of Salmonella spp. resistance in swine spurs the search for alternatives to antibiotics. Microcin J25 (MccJ25), a bacteriocin produced by Escherichia coli, is a potent inhibitor of several pathogenic bacteria including Salmonella… read more here.
Keywords: microbiota; impact microcin; porcine; microcin j25 ... See more keywords
Lasso Peptide Microcin J25 Effectively Enhances Gut Barrier Function and Modulates Inflammatory Response in an Enterotoxigenic Escherichia coli-Challenged Mouse Model
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DOI: 10.3390/ijms21186500
Abstract: Bacterial resistance leads to severe public health and safety issues worldwide. Alternatives to antibiotics are currently needed. A promising lasso peptide, microcin J25 (MccJ25), is considered to be the best potential substitute for antibiotics to… read more here.
Keywords: peptide microcin; escherichia coli; lasso peptide; barrier function ... See more keywords