Improving the Recall Performance of a Brain Mimetic Microcircuit Model
Sign Up to like & getrecommendations! Published in 2019 at "Cognitive Computation"
DOI: 10.1007/s12559-019-09658-8
Abstract: The recall performance of a well-established canonical microcircuit model of the hippocampus, a region of the mammalian brain that acts as a short-term memory, was systematically evaluated. All model cells were simplified compartmental models with… read more here.
Keywords: recall performance; model; microcircuit; brain ... See more keywords
Differences in subcortico-cortical interactions identified from connectome and microcircuit models in autism
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-21732-0
Abstract: The pathophysiology of autism has been suggested to involve a combination of both macroscale connectome miswiring and microcircuit anomalies. Here, we combine connectome-wide manifold learning with biophysical simulation models to understand associations between global network… read more here.
Keywords: cortical interactions; subcortico cortical; autism; microcircuit ... See more keywords
Theta-gamma phase amplitude coupling in a hippocampal CA1 microcircuit
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Computational Biology"
DOI: 10.1371/journal.pcbi.1010942
Abstract: Phase amplitude coupling (PAC) between slow and fast oscillations is found throughout the brain and plays important functional roles. Its neural origin remains unclear. Experimental findings are often puzzling and sometimes contradictory. Most computational models… read more here.
Keywords: phase amplitude; ca1 microcircuit; gamma; amplitude coupling ... See more keywords
Discovering Microcircuit Secrets With Multi-Spot Imaging and Electrophysiological Recordings: The Example of Cerebellar Network Dynamics
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.805670
Abstract: The cerebellar cortex microcircuit is characterized by a highly ordered neuronal architecture having a relatively simple and stereotyped connectivity pattern. For a long time, this structural simplicity has incorrectly led to the idea that anatomical… read more here.
Keywords: electrophysiological recordings; imaging electrophysiological; cerebellar network; discovering microcircuit ... See more keywords
neuroAIx-Framework: design of future neuroscience simulation systems exhibiting execution of the cortical microcircuit model 20× faster than biological real-time
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Computational Neuroscience"
DOI: 10.3389/fncom.2023.1144143
Abstract: Introduction Research in the field of computational neuroscience relies on highly capable simulation platforms. With real-time capabilities surpassed for established models like the cortical microcircuit, it is time to conceive next-generation systems: neuroscience simulators providing… read more here.
Keywords: neuroscience; time; framework; real time ... See more keywords
Simulating the Cortical Microcircuit Significantly Faster Than Real Time on the IBM INC-3000 Neural Supercomputer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2021.728460
Abstract: This article employs the new IBM INC-3000 prototype FPGA-based neural supercomputer to implement a widely used model of the cortical microcircuit. With approximately 80,000 neurons and 300 Million synapses this model has become a benchmark… read more here.
Keywords: neural supercomputer; ibm inc; time; microcircuit ... See more keywords
Functional Investigation of a Neuronal Microcircuit in the CA1 Area of the Hippocampus Reveals Synaptic Dysfunction in Dravet Syndrome Mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.823640
Abstract: Dravet syndrome is severe childhood-onset epilepsy, caused by loss of function mutations in the SCN1A gene, encoding for the voltage-gated sodium channel NaV1.1. The leading hypothesis is that Dravet is caused by selective reduction in… read more here.
Keywords: ca1; ca1 pyramidal; dravet syndrome; mice ... See more keywords