A designed bacterial microcompartment shell with tunable composition and precision cargo loading.
Sign Up to like & getrecommendations! Published in 2019 at "Metabolic engineering"
DOI: 10.1016/j.ymben.2019.04.011
Abstract: Microbes often augment their metabolism by conditionally constructing proteinaceous organelles, known as bacterial microcompartments (BMCs), that encapsulate enzymes to degrade organic compounds or assimilate CO2. BMCs self-assemble and are spatially delimited by a semi-permeable shell… read more here.
Keywords: designed bacterial; bacterial microcompartment; microcompartment shell; shell ... See more keywords
In Vitro Assembly of Diverse Bacterial Microcompartment Shell Architectures.
Sign Up to like & getrecommendations! Published in 2018 at "Nano letters"
DOI: 10.1021/acs.nanolett.8b02991
Abstract: Bacterial microcompartments (BMCs) are organelles composed of a selectively permeable protein shell that encapsulates enzymes involved in CO2 fixation (carboxysomes) or carbon catabolism (metabolosomes). Confinement of sequential reactions by the BMC shell presumably increases the… read more here.
Keywords: diverse bacterial; vitro assembly; bacterial microcompartment; assembly diverse ... See more keywords
Assembly principles and structure of a 6.5-MDa bacterial microcompartment shell
Sign Up to like & getrecommendations! Published in 2017 at "Science"
DOI: 10.1126/science.aan3289
Abstract: How to make a protein-based nanocontainer Bacterial microcompartments are to bacteria what membrane-bound organelles are to eukaryotic cells. They are specialized subcellular compartments for colocalizing enzymes to enhance reaction rates, protect sensitive proteins, and sequester… read more here.
Keywords: assembly principles; bacterial microcompartment; structure; microcompartment shell ... See more keywords