Microcrystal Electron Diffraction-Guided Discovery of Fungal Metabolites
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DOI: 10.1021/jacs.5c01466
Abstract: Nature remains a vast repository of complex and functional metabolites whose structural characterization continues to drive innovations in pharmaceuticals, agrochemicals, and materials science. The cryogenic electron microscopy (cryoEM) method, microcrystal electron diffraction (microED, a 3D… read more here.
Keywords: diffraction guided; electron diffraction; microcrystal electron; electron ... See more keywords
The cryo-EM method microcrystal electron diffraction (MicroED)
Sign Up to like & getrecommendations! Published in 2019 at "Nature Methods"
DOI: 10.1038/s41592-019-0395-x
Abstract: In 2013 we established a cryo-electron microscopy (cryo-EM) technique called microcrystal electron diffraction (MicroED). Since that time, data collection and analysis schemes have been fine-tuned, and structures for more than 40 different proteins, oligopeptides and… read more here.
Keywords: technique; microcrystal electron; diffraction microed; electron diffraction ... See more keywords
Selecting a stable solid form of remdesivir using microcrystal electron diffraction and crystal structure prediction
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DOI: 10.1039/d1ra03100g
Abstract: Therapeutic options in response to the coronavirus disease 2019 (COVID-19) outbreak are urgently needed. In this communication, we demonstrate how to support selection of a stable solid form of an antiviral drug remdesivir in quick… read more here.
Keywords: form; solid form; electron diffraction; microcrystal electron ... See more keywords
A comparison of microcrystal electron diffraction and X-ray powder diffraction for the structural analysis of metal–organic frameworks
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DOI: 10.1107/s1600576724012068
Abstract: Microcrystal electron diffraction (microED) was used to determine the crystal structure of a recently synthesized metal–organic framework (MOF) from powder crystallites. The structural descriptions of two other MOFs by microED are compared with results previously… read more here.
Keywords: electron diffraction; microcrystal electron; diffraction; powder ... See more keywords
Comparing serial X-ray crystallography and microcrystal electron diffraction (MicroED) as methods for routine structure determination from small macromolecular crystals
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DOI: 10.1107/s205225252000072x
Abstract: Serial X-ray crystallography and microcrystal electron diffraction were performed using microcrystals of the enzyme cyclophilin A. The results highlight the strengths and weakness of the two complementary methods. read more here.
Keywords: microcrystal electron; crystallography microcrystal; serial ray; ray crystallography ... See more keywords