Intracerebral microdialysis coupled to LC-MS/MS for the determination tramadol and its major pharmacologically active metabolite O-desmethyltramadol in rat brain microdialysates.
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DOI: 10.1002/dta.2157
Abstract: A rapid and sensitive method involving liquid chromatography electrospray tandem mass spectrometry (LC-ESI-MS/MS) coupled to an intracerebral microdialysis technique was developed for the determination and pharmacokinetic investigation of tramadol and its major active metabolite O-desmethyltramadol… read more here.
Keywords: rat brain; microdialysis; intracerebral microdialysis; tramadol ... See more keywords
Intratumoral retrograde microdialysis treatment of high-grade glioma with cisplatin
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DOI: 10.1007/s00701-020-04488-2
Abstract: This study evaluates the application of a microdialysis technique for interstitial chemotherapy using cisplatin in high-grade glioma. An in vitro study demonstrated that cisplatin can be administered through retrograde microdialysis and defined the recovery for… read more here.
Keywords: grade glioma; high grade; microdialysis; treatment ... See more keywords
Assessment of changes in blood glucose concentration with intravascular microdialysis
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DOI: 10.1007/s10877-018-0111-x
Abstract: Blood glucose and its variability of is a major prognostic factor associated with morbidity. We hypothesized that intravenous microdialysis incorporated in a central venous catheter (CVC) would be interchangeable with changes in blood glucose measured… read more here.
Keywords: glucose measurements; microdialysis; changes blood; blood glucose ... See more keywords
High voriconazole target‐site exposure after approved sequence dosing due to nonlinear pharmacokinetics assessed by long‐term microdialysis
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DOI: 10.1016/j.ejps.2019.02.001
Abstract: &NA; Voriconazole, a broad‐spectrum antifungal drug used to prevent and treat invasive fungal infections, shows complex pharmacokinetics and is primarily metabolised by various CYP enzymes. An adequate unbound antibiotic concentration‐time profile at the target‐site of… read more here.
Keywords: sequence dosing; microdialysis; approved sequence; target site ... See more keywords
In vivo characterization of metabolic activity and oxidative stress in grafted human ovarian tissue using microdialysis.
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DOI: 10.1016/j.fertnstert.2018.04.009
Abstract: OBJECTIVE To characterize oxidative stress and metabolic activity in xenografted human ovarian tissue using microdialysis. DESIGN Prospective experimental study. SETTING Gynecology research unit at a university hospital. PATIENT(S) Cryopreserved ovarian cortex from five women 27-35 years… read more here.
Keywords: microdialysis; ovarian tissue; metabolic activity; tissue ... See more keywords
On-line coupling of capillary electrophoresis with microdialysis for determining saccharides in dairy products and honey.
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DOI: 10.1016/j.foodchem.2020.126362
Abstract: Free sucrose, lactose, galactose, glucose and fructose were determined in yoghurts, milk and honey using on-line coupling of capillary electrophoresis with microdialysis. The dairy products were diluted 50-fold with 10 mmol/L NaOH and sampled using laboratory-made… read more here.
Keywords: capillary electrophoresis; coupling capillary; microdialysis; line coupling ... See more keywords
The application of bathophenanthroline for the determination of free iron in parallel with hROS in microdialysis samples
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DOI: 10.1016/j.jneumeth.2019.108530
Abstract: BACKGROUND Free, non-protein bound, Fe(II), which can catalyse the formation of the toxic highly-reactive oxygen species (hROS), has been implicated in several neurodegenerative conditions. The determination of free Fe(II) and Fe(III) in samples obtained from… read more here.
Keywords: sample; microdialysis samples; determination free; microdialysis ... See more keywords
Recovery rates of combination antibiotic therapy using in vitro microdialysis simulating in vivo conditions
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DOI: 10.1016/j.jpha.2018.07.003
Abstract: Microdialysis is a technique used to measure the unbound antibiotic concentration in the interstitial spaces, the target site of action. In vitro recovery studies are essential to calibrating the microdialysis system for in vivo studies.… read more here.
Keywords: recovery; combination antibiotic; microdialysis; recovery rates ... See more keywords
Regional cerebral blood flow and cellular environment in subarachnoid hemorrhage: A thermal doppler flowmetry and microdialysis study.
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DOI: 10.1016/j.pjnns.2016.11.002
Abstract: BACKGROUND Cerebral microdialysis enables assessment of regional metabolic physiology and provides biomarkers for clinical correlation in critical conditions, such as subarachnoid hemorrhage (SAH). The aim of our current study was to investigate the correlation between… read more here.
Keywords: blood flow; microdialysis; cerebral blood; ratio ... See more keywords
Gas phase microdialysis and chemiluminescence detection: A small, fast, selective, and sensitive method to monitor aqueous nitric oxide.
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DOI: 10.1016/j.talanta.2021.122599
Abstract: A method using a gas-phase microdialysis probe interfaced with a modified commercially available nitric oxide (NO) detector is shown to selectively measure aqueous NO at low μM levels with high selectivity. The detector measures chemiluminescence… read more here.
Keywords: gas phase; microdialysis; phase microdialysis; method ... See more keywords
Development of an In Vivo Retrodialysis Calibration Method Using Stable Isotope Labeling to Monitor Metabolic Pathways in the Tumor Microenvironment via Microdialysis.
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DOI: 10.1016/j.xphs.2019.05.016
Abstract: Microdialysis is a technique that utilizes a semipermeable membrane to sample analytes present within tissue interstitial fluid. Analyte-specific calibration is required for quantitative microdialysis, but these calibration methods are tedious, require significant technical skill, and… read more here.
Keywords: method using; isotope; microdialysis; calibration ... See more keywords