Evaluation of CYP2C19 activity using microdosed oral omeprazole in humans.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of clinical pharmacology"
DOI: 10.1007/s00228-022-03304-3
Abstract: PURPOSE To investigate the suitability of microdosed oral omeprazole for predicting CYP2C19 activity in vivo in combination with simultaneous assessment of CYP3A and CYP2D6 activity using both microdosed midazolam and yohimbine. METHODS An open, fixed-sequence… read more here.
Keywords: oral omeprazole; cyp2c19 activity; microdosed oral; activity ... See more keywords
Quantification of microdosed oral yohimbine and its major metabolite in human plasma in the picogram range.
Sign Up to like & getrecommendations! Published in 2019 at "Bioanalysis"
DOI: 10.4155/bio-2019-0129
Abstract: Aim: Pharmacokinetics after oral microdosing of the anticipated CYP2D6 substrate yohimbine and its metabolite 11-OH-yohimbine is potentially useful for drug-drug interaction trials and profiling of CYP2D6 enzyme activity. Materials & methods: We developed an ultrasensitive… read more here.
Keywords: plasma; range; microdosed oral; quantification microdosed ... See more keywords