Application of a high-density microelectrode array assay using a 3D human iPSC-derived brain microphysiological system model for in vitro neurotoxicity screening of environmental compounds
Sign Up to like & getrecommendations! Published in 2025 at "Archives of Toxicology"
DOI: 10.1007/s00204-025-04043-x
Abstract: Unraveling the associations between human exposure to environmental chemicals and potential neurotoxicity presents significant challenges. Evaluation of neurotoxicity potential using animal testing is resource-intensive (financial, labor, and animal use) and faces uncertainties regarding biological relevance… read more here.
Keywords: neurotoxicity; microelectrode array; mea assay; ipsc derived ... See more keywords
A patterned polystyrene-based microelectrode array for in vitro neuronal recordings
Sign Up to like & getrecommendations! Published in 2018 at "Biomedical Microdevices"
DOI: 10.1007/s10544-018-0295-3
Abstract: Substrate-integrated microelectrode arrays (MEAs) are non-invasive platforms for recording supra-threshold signals, i.e. action potentials or spikes, from a variety of cultured electrically active cells, and are useful for pharmacological and toxicological studies. However, the MEA… read more here.
Keywords: polystyrene based; vitro neuronal; microelectrode array; array vitro ... See more keywords
Improvements to multiwell microelectrode array technology for characterization of neural and cardiac electrophysiology in vitro
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Pharmacological and Toxicological Methods"
DOI: 10.1016/j.vascn.2018.01.400
Abstract: The MaestroTM Pro (left) and MaestroTM Edge (right) offer the latest MEA technology for optimal data The flexibility and accessibility of induced pluripotent stem cell (iPSC) technology has allowed complex human biology to be reproduced… read more here.
Keywords: multiwell microelectrode; improvements multiwell; microelectrode array; technology ... See more keywords
High-Throughput PEDOT:PSS/PtNPs-Modified Microelectrode Array for Simultaneous Recording and Stimulation of Hippocampal Neuronal Networks in Gradual Learning Process.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.1c23170
Abstract: When it comes to mechanisms of brain functions such as learning and memory mediated by neural networks, existing multichannel electrophysiological detection and regulation technology at the cellular level does not suffice. To address this challenge,… read more here.
Keywords: microelectrode array; stimulation; learning process; pss ptnps ... See more keywords
Wireless, miniaturized, semi-implantable electrocorticography microsystem validated in vivo
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-77953-8
Abstract: This paper reports on the design, development, and test of a multi-channel wireless micro-electrocorticography (µECoG) system. The system consists of a semi-implantable, ultra-compact recording unit and an external unit, interfaced through a 2.4 GHz radio… read more here.
Keywords: validated vivo; system; unit; semi implantable ... See more keywords
A three-dimensional flexible microelectrode array for subretinal stimulation.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of neural engineering"
DOI: 10.1088/1741-2552/ab36ab
Abstract: OBJECTIVE Various retinal prostheses have been developed to restore the vision for blind patients, and some of them are already in clinical use. In this paper, we present a three-dimensional (3D) microelectrode array for a… read more here.
Keywords: three dimensional; array; stimulation; microelectrode array ... See more keywords
A 1280-Channel Neural Microelectrode Array With Complementary Wedge-Shaped 3-D Assembly Interfaces
Sign Up to like & getrecommendations! Published in 2024 at "IEEE Sensors Journal"
DOI: 10.1109/jsen.2024.3377920
Abstract: This article presents a novel 1280-channel 3-D neural microelectrode array with a complementary wedge-shaped interface. The microelectrode array consists of five 256-channel neural microelectrode chips, which are precisely stacked in three dimensions. The bonding interface… read more here.
Keywords: neural microelectrode; wedge shaped; microelectrode array; microelectrode ... See more keywords
Impedance Spectroscopy and Electrophysiological Imaging of Cells With a High-Density CMOS Microelectrode Array System
Sign Up to like & getrecommendations! Published in 2018 at "IEEE Transactions on Biomedical Circuits and Systems"
DOI: 10.1109/tbcas.2018.2881044
Abstract: A monolithic multi-functional CMOS microelectrode array system was developed that enables label-free electrochemical impedance spectroscopy of cells in vitro at high spatiotemporal resolution. The electrode array includes 59,760 platinum microelectrodes, densely packed within a 4.5… read more here.
Keywords: system; microelectrode array; spectroscopy; impedance ... See more keywords
A CMOS Microelectrode Array System With Reconfigurable Sub-Array Multiplexing Architecture Integrating 24,320 Electrodes and 380 Readout Channels
Sign Up to like & getrecommendations! Published in 2022 at "IEEE Transactions on Biomedical Circuits and Systems"
DOI: 10.1109/tbcas.2022.3211275
Abstract: This article presents a CMOS microelectrode array (MEA) system with a reconfigurable sub-array multiplexing architecture using the time-division multiplexing (TDM) technique. The system consists of 24,320 TiN electrodes with 17.7 μm-pitch pixels and 380 column-parallel… read more here.
Keywords: system; cmos microelectrode; readout channels; microelectrode array ... See more keywords
Dorsal root ganglia neurite outgrowth measured as a function of changes in microelectrode array resistance
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0175550
Abstract: Current research in prosthetic device design aims to mimic natural movements using a feedback system that connects to the patient's own nerves to control the device. The first step in using neurons to control motion… read more here.
Keywords: array; root ganglia; microelectrode array; dorsal root ... See more keywords
PtNPs/Short MWCNT-PEDOT: PSS-Modified Microelectrode Array to Detect Neuronal Firing Patterns in the Dorsal Raphe Nucleus and Hippocampus of Insomnia Rats
Sign Up to like & getrecommendations! Published in 2022 at "Micromachines"
DOI: 10.3390/mi13030488
Abstract: Research on the intracerebral mechanism of insomnia induced by serotonin (5-HT) deficiency is indispensable. In order to explore the effect of 5-HT deficiency-induced insomnia on brain regions related to memory in rats, we designed and… read more here.
Keywords: insomnia rats; hippocampus insomnia; insomnia; microelectrode array ... See more keywords