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Published in 2018 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.12.027
Abstract: The study first aimed to apply a design of experiment (DoE) approach to investigate the influences of excipients on the properties of liquid self-microemulsifying drug delivery system (SMEDDS) and SMEDDS loaded in the pellet (pellet-SMEDDS)… read more here.
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Published in 2021 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2021.102771
Abstract: Abstract The current work deals with the designing of a solid self-microemulsifying drug delivery system (S-SMEDDS) of eprosartan mesylate (EPM) for improved bioavailability by enhancing the intestinal permeability of EPM. Two L-SMEDDSs containing EPM (OF9… read more here.
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Published in 2019 at "Ocular Immunology and Inflammation"
DOI: 10.1080/09273948.2017.1333622
Abstract: ABSTRACT Purpose: The purpose of this study was to investigate the self-microemulsifying drug delivery systems (SMEDDS) for ophthalmic delivery of Prednisolone (PDN) to treat uveitis. Materials and methods: The pseudo-ternary phase diagrams were developed, and… read more here.
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Published in 2022 at "Drug Delivery"
DOI: 10.1080/10717544.2022.2086939
Abstract: Abstract Olmesartan medoxomil (OM) is an angiotensin receptor blocker. This study aimed to investigate the effects of OM self-microemulsifying drug delivery system (OMS) in trinitrobenzene sulfonic acid (TNBS)-induced acute colitis in rats. Besides two control… read more here.
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Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-2238
Abstract: Pancreatic cancer (PC) is the fourth leading cause of deaths in the United States, claiming approximately 43,000 lives every year. Existing trends suggest that it will be the second cause of death after lung cancer… read more here.
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Published in 2018 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-018-1067-3
Abstract: The study was performed aiming to enhance the solubility and oral bioavailability of poorly water-soluble drug osthole by formulating solid self-microemulsifying drug delivery system (S-SMEDDS) via spherical crystallization technique. Firstly, the liquid self-microemulsifying drug delivery… read more here.
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Published in 2019 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2019.00978
Abstract: Purpose: To develop a triptolide (TP) self-microemulsifying drug delivery system and to investigate its anti-tumor effect on human gastric cancer line MGC80-3 xenografts in nude mice. Methods: The medium chain triglyceride (MCT) was selected as… read more here.
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Published in 2023 at "Pharmaceuticals"
DOI: 10.3390/ph16020283
Abstract: Oral delivery has become the route of choice among all other types of drug administrations. However, typical chronic disease drugs are often poorly water-soluble, have low dissolution rates, and undergo first-pass metabolism, ultimately leading to… read more here.