Microengineered 3D pulmonary interstitial mimetics highlight a critical role for matrix degradation in myofibroblast differentiation
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DOI: 10.1126/sciadv.abb5069
Abstract: Tissue-engineered fibrosis model highlights distinct cell responses to matrix stiffness and drug treatment in 2D versus 3D. Fibrosis, characterized by aberrant tissue scarring from activated myofibroblasts, is often untreatable. Although the extracellular matrix becomes increasingly… read more here.
Keywords: myofibroblast differentiation; fibrosis; matrix; microengineered pulmonary ... See more keywords