Arachidonic acid, a clinically adverse mediator in the ovarian cancer microenvironment, impairs JAK-STAT signaling in macrophages by perturbing lipid raft structures.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular oncology"
DOI: 10.1002/1878-0261.13221
Abstract: Survival of ovarian carcinoma is associated with the abundance of immunosuppressed CD163high CD206high tumor-associated macrophages (TAMs) and high levels of arachidonic acid (AA) in the tumor microenvironment. Here, we show that both associations are functionally… read more here.
Keywords: raft; lipid raft; microenvironment; acid clinically ... See more keywords
The breast cancer microenvironment and lipoprotein lipase: Another negative notch for a beneficial enzyme?
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13559
Abstract: The energy demand of breast cancers is in part met through the β‐oxidation of exogenous fatty acids. Fatty acids may also be used to aid in cell signaling and toward the construction of new membranes… read more here.
Keywords: breast cancer; breast; lipoprotein lipase; microenvironment ... See more keywords
Inflammation‐Instructed Hierarchical Delivery of IL‐4/miR‐21 Orchestrates Osteoimmune Microenvironment toward the Treatment of Rheumatoid Arthritis
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DOI: 10.1002/adfm.202101033
Abstract: Dysregulated inflammation and failure in resolution account for the incidence and deterioration of rheumatoid arthritis (RA). IL‐4 and miR‐21 possess complementary functions in inhibiting inflammation and fostering resolution. Thus, inflammation‐instructed nanocomplexes (NCs) are herein developed… read more here.
Keywords: arthritis; mir; delivery mir; microenvironment ... See more keywords
Translational Nanotherapeutics Reprograms Immune Microenvironment in Malignant Pleural Effusion of Lung Adenocarcinoma.
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DOI: 10.1002/adhm.202100149
Abstract: Malignant pleural effusion (MPE) remains a treatment bottleneck in advanced lung cancer, due to its complicated microenvironments and "cold" immunity. Therefore, the search for therapeutic drugs to transform MPE to functionally "hot" one could advance… read more here.
Keywords: microenvironment; mpe; malignant pleural; pleural effusion ... See more keywords
Vascularized lung cancer model for evaluating the promoted transport of anticancer drugs and immune cells in an engineered tumor microenvironment.
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DOI: 10.1002/adhm.202102581
Abstract: The tumor microenvironment (TME) is the environment around the tumor, including blood vessels, immune cells, fibroblasts, signaling molecules, and the extracellular matrix (ECM). Owing to its component interactions, the TME influences tumor growth and drug… read more here.
Keywords: tumor; cancer; immune cells; microenvironment ... See more keywords
Regulating Macrophage Polarization in High Glucose Microenvironment Using Lithium‐Modified Bioglass‐Hydrogel for Diabetic Bone Regeneration
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DOI: 10.1002/adhm.202200298
Abstract: Diabetes mellitus is a chronic metabolic disease with a proinflammatory microenvironment, causing poor vascularization and bone regeneration. Due to the lack of effective therapy and one‐sided focus on the direct angiogenic properties of biomaterials and… read more here.
Keywords: diabetic bone; microenvironment; hydrogel; bone ... See more keywords
Architecture‐Engineered Electrospinning Cascade Regulates Spinal Microenvironment to Promote Nerve Regeneration
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202202658
Abstract: The inflammatory cascade after spinal cord injury (SCI) causes necrotizing apoptosis of local stem cells, which limits nerve regeneration. Therefore, coordinating the inflammatory immune response and neural stem cell (NSC) functions is key to promoting… read more here.
Keywords: regeneration; sci; system; microenvironment ... See more keywords
Integrated Cascade Nanozyme Remodels Chondrocyte Inflammatory Microenvironment in Temporomandibular Joint Osteoarthritis via Inhibiting ROS‐NF‐κB and MAPK Pathways
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DOI: 10.1002/adhm.202203195
Abstract: Temporomandibular joint osteoarthritis (TMJ OA) is a degenerative joint disease with no complete cure at present. Notably, the inflammatory microenvironment in TMJ OA is modulated by oxidative stress, which impacts cartilage metabolism, chondrocyte apoptosis, inflammatory… read more here.
Keywords: inhibiting ros; microenvironment; inflammatory microenvironment; temporomandibular joint ... See more keywords
Oxidative Stimuli-responsive "pollen-like" Exosomes from Silver Nanoflowers Remodeling Diabetic Wound Microenvironment for Accelerating wound Healing.
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DOI: 10.1002/adhm.202300456
Abstract: The hostile oxidative wound microenvironment, defective angiogenesis and uncontrolled release of therapeutic factors are major challenges in improving the diabetic wound healing. Herein, adipose-derived stem cell (ADSC)-derived exosomes (Exos) were firstly loaded into Ag@bovine serum… read more here.
Keywords: wound; microenvironment; wound healing; wound microenvironment ... See more keywords
Engineering the NiNC Catalyst Microenvironment Enabling CO2 Electroreduction with Nearly 100% CO Selectivity in Acid
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DOI: 10.1002/adma.202201295
Abstract: CO2 electrolysis in acid has emerged as a promising route to achieve high CO2 utilization due to the inhibition of undesired carbonate formation that generally occurs in alkaline or neutral conditions. However, the efficiency and… read more here.
Keywords: ptfe; microenvironment; catalyst; nearly 100 ... See more keywords
A Novel “Inside‐Out” Intraocular Nanomedicine Delivery Mode for Nanomaterials’ Biological Effect Enhanced Choroidal Neovascularization Occlusion and Microenvironment Regulation
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DOI: 10.1002/adma.202209690
Abstract: Photodynamic therapy (PDT) is commonly used in choroidal neovascularization (CNV) treatment due to the superior light transmittance of the eye. However, PDT often leads to surrounding tissue damage and further microenvironmental deterioration, including exacerbated hypoxia,… read more here.
Keywords: microenvironment; cnv; occlusion; choroidal neovascularization ... See more keywords