Arachidonic acid, a clinically adverse mediator in the ovarian cancer microenvironment, impairs JAK-STAT signaling in macrophages by perturbing lipid raft structures.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular oncology"
DOI: 10.1002/1878-0261.13221
Abstract: Survival of ovarian carcinoma is associated with the abundance of immunosuppressed CD163high CD206high tumor-associated macrophages (TAMs) and high levels of arachidonic acid (AA) in the tumor microenvironment. Here, we show that both associations are functionally… read more here.
Keywords: raft; lipid raft; microenvironment; acid clinically ... See more keywords
The breast cancer microenvironment and lipoprotein lipase: Another negative notch for a beneficial enzyme?
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13559
Abstract: The energy demand of breast cancers is in part met through the β‐oxidation of exogenous fatty acids. Fatty acids may also be used to aid in cell signaling and toward the construction of new membranes… read more here.
Keywords: breast cancer; breast; lipoprotein lipase; microenvironment ... See more keywords
Inflammation‐Instructed Hierarchical Delivery of IL‐4/miR‐21 Orchestrates Osteoimmune Microenvironment toward the Treatment of Rheumatoid Arthritis
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DOI: 10.1002/adfm.202101033
Abstract: Dysregulated inflammation and failure in resolution account for the incidence and deterioration of rheumatoid arthritis (RA). IL‐4 and miR‐21 possess complementary functions in inhibiting inflammation and fostering resolution. Thus, inflammation‐instructed nanocomplexes (NCs) are herein developed… read more here.
Keywords: arthritis; mir; delivery mir; microenvironment ... See more keywords
A Versatile Passivated Protein‐Adsorption Platform for Rapid Healing of Vascular Stents by Modulating the Microenvironment
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DOI: 10.1002/adfm.202312243
Abstract: Biodegradable stents have paved the way to treat coronary artery disease. However, rapid reendothelialization is required to solve the problems of mismatched degradation rates, localized inflammation, and insufficient biocompatibility. Herein, a novel passivated protein‐adsorption coating… read more here.
Keywords: passivated protein; adsorption; protein adsorption; microenvironment ... See more keywords
Ultrasound Tissue Engineering Technology for Regulating Immune Microenvironment
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DOI: 10.1002/adfm.202400656
Abstract: The immune microenvironment is critical for the occurrence, progression, and treatment of diseases. Ultrasound tissue engineering technology utilizes ultrasound and the principles of tissue engineering to repair, regenerate, and functionally reconstruct biological tissues. Ultrasound therapy… read more here.
Keywords: engineering technology; tissue engineering; microenvironment; ultrasound tissue ... See more keywords
Inhibitory Microenvironment Remodeling Enhances STING Activation for Solid Tumor Immunotherapy
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DOI: 10.1002/adfm.202421849
Abstract: The immunomodulatory effect of the interferon gene‐stimulating factor (STING) pathway makes it an important target for tumor immunotherapy, which, however, suffers from the easy degradation and deteriorated stimulatory capacity of current STING agonists in the… read more here.
Keywords: tumor immunotherapy; microenvironment; sting agonists; tumor ... See more keywords
Interfacial Confined Oxidation‐Assisted Construction of Black Bioceramic Coating on Metal Implants for Therapy and Regeneration by On‐Demand Remodeling Pathological Microenvironment
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202516400
Abstract: The commonly used metal bone implants fail to specifically modulate pathological microenvironments to exert therapeutic or reparative efficacy in tricky diseases such as osteosarcoma. Herein, a novel “Interfacial confined oxidation” (ICO) strategy has been proposed… read more here.
Keywords: black bioceramic; microenvironment; confined oxidation; bioceramic coating ... See more keywords
Translational Nanotherapeutics Reprograms Immune Microenvironment in Malignant Pleural Effusion of Lung Adenocarcinoma.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202100149
Abstract: Malignant pleural effusion (MPE) remains a treatment bottleneck in advanced lung cancer, due to its complicated microenvironments and "cold" immunity. Therefore, the search for therapeutic drugs to transform MPE to functionally "hot" one could advance… read more here.
Keywords: microenvironment; mpe; malignant pleural; pleural effusion ... See more keywords
Vascularized lung cancer model for evaluating the promoted transport of anticancer drugs and immune cells in an engineered tumor microenvironment.
Sign Up to like & getrecommendations! Published in 2022 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202102581
Abstract: The tumor microenvironment (TME) is the environment around the tumor, including blood vessels, immune cells, fibroblasts, signaling molecules, and the extracellular matrix (ECM). Owing to its component interactions, the TME influences tumor growth and drug… read more here.
Keywords: tumor; cancer; immune cells; microenvironment ... See more keywords
Regulating Macrophage Polarization in High Glucose Microenvironment Using Lithium‐Modified Bioglass‐Hydrogel for Diabetic Bone Regeneration
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DOI: 10.1002/adhm.202200298
Abstract: Diabetes mellitus is a chronic metabolic disease with a proinflammatory microenvironment, causing poor vascularization and bone regeneration. Due to the lack of effective therapy and one‐sided focus on the direct angiogenic properties of biomaterials and… read more here.
Keywords: diabetic bone; microenvironment; hydrogel; bone ... See more keywords
Architecture‐Engineered Electrospinning Cascade Regulates Spinal Microenvironment to Promote Nerve Regeneration
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202202658
Abstract: The inflammatory cascade after spinal cord injury (SCI) causes necrotizing apoptosis of local stem cells, which limits nerve regeneration. Therefore, coordinating the inflammatory immune response and neural stem cell (NSC) functions is key to promoting… read more here.
Keywords: regeneration; sci; system; microenvironment ... See more keywords