Roles and interactions of tumor microenvironment components in medulloblastoma with implications for novel therapeutics
Sign Up to like & getrecommendations! Published in 2024 at "Genes"
DOI: 10.1002/gcc.23233
Abstract: Medulloblastomas, the most common malignant pediatric brain tumors, can be classified into the wingless, sonic hedgehog (SHH), group 3, and group 4 subgroups. Among them, the SHH subgroup with the TP53 mutation and group 3… read more here.
Keywords: components medulloblastoma; microenvironment components; tumor microenvironment; medulloblastoma implications ... See more keywords
Abstract LB-B26: Novel eIF4A inhibitors target both cellular and microenvironment components in pancreatic ductal adenocarcinoma
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-17-lb-b26
Abstract: We are investigating the potential utility of targeting protein translation via inhibiting the translation initiation factor 4A (eIF4A) with a new class of Pateamine A derivatives to treat pancreatic ductal adenocarcinoma (PDAC). PDAC is one… read more here.
Keywords: microenvironment components; cellular microenvironment; pancreatic ductal; ductal adenocarcinoma ... See more keywords
Tumor Immune Microenvironment Components and Checkpoint Molecules in Anaplastic Variant of Diffuse Large B-Cell Lymphoma
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.638154
Abstract: Background Anaplastic diffuse large B-cell lymphoma(A-DLBCL) is a rare morphological subtype characterized by the presence of polygonal, bizarre-shaped tumor cells. Our previous research found that A-DLBCL displays many genetic alterations and biological features that differ… read more here.
Keywords: dlbcl; immune microenvironment; tumor immune; microenvironment components ... See more keywords
Single-cell profiling of microenvironment components by spatial localization in pancreatic ductal adenocarcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Theranostics"
DOI: 10.7150/thno.73222
Abstract: Rationale: The biology of the pancreatic ductal adenocarcinoma (PDAC) is heterogenous, but how heterogenity of the tumor microenvironment contributes to disparate patient outcomes remains essentially unstudied. Methods: A strategy employing multiplex digital spatial profiling (mplxDSP)… read more here.
Keywords: microenvironment components; ductal adenocarcinoma; single cell; pancreatic ductal ... See more keywords