Synergy between Clinical Microenvironment Targeted Nanoplatform and Near-Infrared Light Irradiation for Managing Pseudomonas aeruginosa Infections.
Sign Up to like & getrecommendations! Published in 2021 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.1c08132
Abstract: Chronic infections caused by Pseudomonas aeruginosa pose severe threats to human health. Traditional antibiotic therapy has lost its total supremacy in this battle. Here, nanoplatforms activated by the clinical microenvironment are developed to treat P.… read more here.
Keywords: microenvironment; pseudomonas aeruginosa; synergy clinical; clinical microenvironment ... See more keywords
Tumor microenvironment–targeted PROTAC nanoparticle self-assembly broadly predicted by structural descriptors
Sign Up to like & getrecommendations! Published in 2025 at "Science Advances"
DOI: 10.1126/sciadv.adu2292
Abstract: Proteolysis-targeting chimeras (PROTACs) are catalytic protein degraders with promising preclinical activity. The clinical translation of PROTACs has been limited by poor pharmacologic properties and toxicities, in part due to their “non-druglike” characteristics, including large molecular… read more here.
Keywords: microenvironment targeted; tumor microenvironment; self; protacs ... See more keywords
Re-education of the Tumor Microenvironment With Targeted Therapies and Immunotherapies
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.01633
Abstract: The clinical success of cancer immunotherapies targeting PD-1 and CTLA-4 has ignited a substantial research effort to improve our understanding of tumor immunity. Recent studies have revealed that the immune contexture of a tumor influences… read more here.
Keywords: therapies immunotherapies; education tumor; microenvironment targeted; tumor microenvironment ... See more keywords
Immunological microenvironment and targeted therapeutics in multiple sclerosis: new insights in crosstalk between immune niches and CNS
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2025.1604987
Abstract: Multiple sclerosis (MS) is a chronic autoimmune disorder of the central nervous system (CNS) that predominantly affects young adults. However, current disease-modifying therapies demonstrate limited efficacy in addressing progressive disease subtypes, underscoring the urgent need… read more here.
Keywords: microenvironment targeted; multiple sclerosis; immunological microenvironment; therapeutics multiple ... See more keywords
Tumor Microenvironment Targeted Nanotherapy
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2018.01230
Abstract: Recent developments in nanotechnology have brought new approaches to cancer diagnosis and therapy. While enhanced permeability and retention effect promotes nano-chemotherapeutics extravasation, the abnormal tumor vasculature, high interstitial pressure and dense stroma structure limit homogeneous… read more here.
Keywords: microenvironment targeted; nano chemotherapeutics; nanotechnology; tumor microenvironment ... See more keywords