Sexual dimorphism of microglia and synapses during mouse postnatal development
Sign Up to like & getrecommendations! Published in 2018 at "Developmental Neurobiology"
DOI: 10.1002/dneu.22568
Abstract: Microglia participate in synapse remodeling in the cortex and hippocampus during mouse postnatal development. Although sex differences in microglia activity during embryonic development have been reported in these regions, it remains unexplored whether microglia show… read more here.
Keywords: microglia; mouse postnatal; microglia synapses; postnatal development ... See more keywords
Identification of a conserved and acute neurodegeneration‐specific microglial transcriptome in the zebrafish
Sign Up to like & getrecommendations! Published in 2017 at "Glia"
DOI: 10.1002/glia.23083
Abstract: Microglia are brain resident macrophages important for brain development, connectivity, homeostasis and disease. However, it is still largely unclear how microglia functions and their identity are regulated at the molecular level. Although recent transcriptomic studies… read more here.
Keywords: acute neurodegeneration; conserved acute; neurodegeneration specific; microglia ... See more keywords
Synaptotagmin‐11 inhibits cytokine secretion and phagocytosis in microglia
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DOI: 10.1002/glia.23186
Abstract: Cytokine secretion and phagocytosis are key functions of activated microglia. However, the molecular mechanisms underlying their regulation in microglia remain largely unknown. Here, we report that synaptotagmin‐11 (Syt11), a non‐Ca2+‐binding Syt implicated in Parkinson disease… read more here.
Keywords: secretion; microglia; phagocytosis; cytokine secretion ... See more keywords
Microglia damage precedes major myelin breakdown in X‐linked adrenoleukodystrophy and metachromatic leukodystrophy
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DOI: 10.1002/glia.23598
Abstract: X‐linked adrenoleukodystrophy (X‐ALD) and metachromatic leukodystrophy (MLD) are two relatively common examples of hereditary demyelinating diseases caused by a dysfunction of peroxisomal or lysosomal lipid degradation. In both conditions, accumulation of nondegraded lipids leads to… read more here.
Keywords: microglia; linked adrenoleukodystrophy; metachromatic leukodystrophy; damage ... See more keywords
LRP1 deficiency in microglia blocks neuro‐inflammation in the spinal dorsal horn and neuropathic pain processing
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DOI: 10.1002/glia.23599
Abstract: Following injury to the peripheral nervous system (PNS), microglia in the spinal dorsal horn (SDH) become activated and contribute to the development of local neuro‐inflammation, which may regulate neuropathic pain processing. The molecular mechanisms that… read more here.
Keywords: microglia; neuro inflammation; lrp1; neuropathic pain ... See more keywords
Astrocyte immunosenescence and deficits in interleukin 10 signaling in the aged brain disrupt the regulation of microglia following innate immune activation
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DOI: 10.1002/glia.24147
Abstract: Microglia, the innate immune cells of the brain, develops a pro‐inflammatory, “primed” profile with age. Using single‐cell RNA‐sequencing, we confirmed hippocampal microglia of aged mice (18 m.o.) had an amplified (4 h) and prolonged (24 h) neuroinflammatory… read more here.
Keywords: response; brain; microglia; interleukin signaling ... See more keywords
Long‐term priming of hypothalamic microglia is associated with energy balance disturbances under diet‐induced obesity
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24217
Abstract: Exposure of microglia to an inflammatory environment may lead to their priming and exacerbated response to future inflammatory stimuli. Here we aimed to explore hypothalamic microglia priming and its consequences on energy balance regulation. A… read more here.
Keywords: energy balance; hypothalamic microglia; obesity; microglia ... See more keywords
Microglia modulate TNFα-mediated synaptic plasticity.
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DOI: 10.1002/glia.24383
Abstract: The pro-inflammatory cytokine tumor necrosis factor α (TNFα) tunes the capacity of neurons to express synaptic plasticity. It remains, however, unclear how TNFα mediates synaptic positive (=change) and negative (=stability) feedback mechanisms. We assessed effects… read more here.
Keywords: tnf; mediated synaptic; plasticity; tnf mediated ... See more keywords
Stimuli-Responsive Miktoarm Polymer-Based Formulations for Fisetin Delivery and Regulatory Effects in Hyperactive Human Microglia.
Sign Up to like & getrecommendations! Published in 2022 at "Macromolecular bioscience"
DOI: 10.1002/mabi.202200174
Abstract: Branched star polymers offer exciting opportunities in enhancing the efficacy of nanocarriers in delivering biologically active lipophilic agents. We demonstrate that the star polymeric architecture can be leveraged to yield soft nanoparticles of vesicular morphology… read more here.
Keywords: stimuli responsive; miktoarm polymer; human microglia; microglia ... See more keywords
The Cannabinoid WIN 55,212-2 Reduces Delayed Neurologic Sequelae After Carbon Monoxide Poisoning by Promoting Microglial M2 Polarization Through ST2 Signaling
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-019-01429-2
Abstract: Delayed neurologic sequelae (DNS) are among the most serious complications of carbon monoxide (CO) poisoning caused partly by elevated neuroinflammation. WIN 55,212-2, a non-selective agonist of cannabinoid receptors, has been demonstrated to have anti-inflammatory properties… read more here.
Keywords: microglial polarization; microglia; win 212; st2 signaling ... See more keywords
Its complicated: The relationship between alcohol and microglia in the search for novel pharmacotherapeutic targets for alcohol use disorders.
Sign Up to like & getrecommendations! Published in 2019 at "Progress in molecular biology and translational science"
DOI: 10.1016/bs.pmbts.2019.06.011
Abstract: Alcohol use disorder (AUD) is a chronic relapsing disorder with wide-ranging health consequences. Alcohol targets the central nervous system producing neurodegeneration and subsequent cognitive and behavioral deficits, but the mechanisms behind these effects remain unclear.… read more here.
Keywords: alcohol use; microglia; system; alcohol ... See more keywords