Microglia activation in the mPFC mediates anxiety‐like behaviors caused by Staphylococcus aureus strain USA300
Sign Up to like & getrecommendations! Published in 2022 at "Brain and Behavior"
DOI: 10.1002/brb3.2715
Abstract: Introduction: Staphylococcus aureus (S. aureus) is considered as one of the major causative agents of serious hospital‐ and community‐acquired infections. Recent studies have reported that S. aureus infection induced neuroinflammation and was linked with some… read more here.
Keywords: mpfc mediates; mediates anxiety; staphylococcus aureus; aureus ... See more keywords
Stress-Induced Microglia Activation and Monocyte Trafficking to the Brain Underlie the Development of Anxiety and Depression.
Sign Up to like & getrecommendations! Published in 2017 at "Current topics in behavioral neurosciences"
DOI: 10.1007/7854_2016_25
Abstract: Psychosocial stress is capable of causing immune dysregulation and increased neuroinflammatory signaling by repeated activation of the neuroendocrine and autonomic systems that may contribute to the development of anxiety and depression. The stress model of… read more here.
Keywords: development anxiety; anxiety depression; microglia activation; stress induced ... See more keywords
Triptolide up-regulates metabotropic glutamate receptor 5 to inhibit microglia activation in the lipopolysaccharide-induced model of Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2018 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2018.04.006
Abstract: Metabotropic glutamate receptor (mGlu)5 regulates microglia activation, which contributes to inflammation. However, the role of mGlu5 in neuroinflammation associated with Parkinson's disease (PD) remains unclear. Triptolide (T10) exerts potent immunosuppressive and anti-inflammatory effects and protects… read more here.
Keywords: mglu5; t10; microglia activation; induced model ... See more keywords
Minocycline alleviates depression-like symptoms by rescuing decrease in neurogenesis in dorsal hippocampus via blocking microglia activation/phagocytosis
Sign Up to like & getrecommendations! Published in 2021 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2020.11.009
Abstract: Clinical studies examining the potential of anti-inflammatory agents, specifically of minocycline, as a treatment for depression has shown promising results. However, mechanistic insights into the neuroprotective and anti-inflammatory actions of minocycline need to be provided.… read more here.
Keywords: minocycline; depression; neurogenesis; microglia activation ... See more keywords
Nanoceria neuroprotective effects in the light-damaged retina: A focus on retinal function and microglia activation.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental eye research"
DOI: 10.1016/j.exer.2019.107797
Abstract: The use of nanomaterials is an emerging therapeutic approach for the treatment of several pathologies. Cerium oxide nanoparticles have been studied for biomedical application, including neurodegenerative disorders, such as age-related macular degeneration in several animal… read more here.
Keywords: focus; neuroprotective effects; function microglia; retinal function ... See more keywords
Effect of sevoflurane treatment on microglia activation, NF-kB and MAPK activities.
Sign Up to like & getrecommendations! Published in 2019 at "Immunobiology"
DOI: 10.1016/j.imbio.2019.07.004
Abstract: Microglia activation has been implicated in neurodegenerative disease. Sevoflurane is fluorinated methyl isopropyl ether with anti-inflammatory activity. In this study, we evaluated the potential effects of sevoflurane on lipopolysaccharides (LPS)-induced microglia activation. We treated primary… read more here.
Keywords: activation; treatment; effect sevoflurane; microglia activation ... See more keywords
Scutellarin protects against lipopolysaccharide-induced behavioral deficits by inhibiting neuroinflammation and microglia activation in rats.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.106943
Abstract: Depression is a complex and heterogeneous mental disorder. Yet, the mechanisms behind depression remain elusive. Increasing evidence suggests that inflammatory reaction and microglia activation are involved in the pathogenesis of depression. Scutellarin has been found… read more here.
Keywords: activation; scutellarin; microglia activation; lps induced ... See more keywords
MicroRNA-124 modulates neuroinflammation in acute methanol poisoning rats via targeting Krüppel-like factor-6
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2078549
Abstract: ABSTRACT Microglia activation-stimulated neuroinflammation exerts functionally in neurodegenerative diseases like brain injury. Acute methanol poisoning (AMP) is a crucial cause of death and morbidity that possibly leads to neuroinflammation. Studies have manifested that miRNAs can… read more here.
Keywords: mir 124; neuroinflammation; amp; acute methanol ... See more keywords
Microglia Activation in the Midbrain of the Human Neonate: The Effect of Perinatal Hypoxic-Ischemic Injury.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of neuropathology and experimental neurology"
DOI: 10.1093/jnen/nlab135
Abstract: Perinatal hypoxia-ischemia (PHI) is a major risk factor for the development of neuropsychiatric deficits later in life. We previously reported that after prolonged PHI, the dopaminergic neurons of the human neonate showed a dramatic reduction… read more here.
Keywords: human neonate; phi; midbrain human; activation midbrain ... See more keywords
Polio Virotherapy Targets the Malignant Glioma Myeloid Infiltrate with Diffuse Microglia Activation Engulfing the CNS.
Sign Up to like & getrecommendations! Published in 2023 at "Neuro-oncology"
DOI: 10.1093/neuonc/noad052
Abstract: BACKGROUND Malignant gliomas commandeer dense inflammatory infiltrates with glioma-associated macrophages and microglia (GAMM) promoting immune suppression, -evasion, and tumor progression. Like all cells in the mononuclear phagocytic system, GAMM constitutively express the poliovirus receptor, CD155.… read more here.
Keywords: polio virotherapy; infiltrate; microglia activation; activation ... See more keywords
Triptolide Suppressed the Microglia Activation to Improve Spinal Cord Injury Through miR-96/IKKβ/NF-κB Pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Spine"
DOI: 10.1097/brs.0000000000002989
Abstract: STUDY DESIGN The effect of triptolide on spinal cord injury (SCI) and inflammatory response was observed by establishing SCI rat model. And in vitro experiments were conducted to determine the underlying mechanism of triptolide-mediated in… read more here.
Keywords: activation; triptolide suppressed; microglia activation; mir ikk ... See more keywords