Microglia in Alzheimer's Disease: Exploring How Genetics and Phenotype Influence Risk.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2019.01.045
Abstract: Research into the function of microglia has dramatically accelerated during the last few years, largely due to recent genetic findings implicating microglia in virtually every neurodegenerative disorder. In Alzheimer's disease (AD), a majority of risk… read more here.
Keywords: risk; microglia alzheimer; alzheimer disease; genetics ... See more keywords
The involvement of microglia in Alzheimer's disease: a new dog in the fight
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Pharmacology"
DOI: 10.1111/bph.14546
Abstract: First described clinically in 1906, Alzheimer's disease (AD) is the most common neurodegenerative disease and form of dementia worldwide. Despite its prevalence, only five therapies are currently approved for AD, all dealing with the symptoms… read more here.
Keywords: disease new; microglia alzheimer; alzheimer disease; involvement microglia ... See more keywords
Targeting Microglia in Alzheimer’s Disease: From Molecular Mechanisms to Potential Therapeutic Targets for Small Molecules
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27134124
Abstract: Alzheimer’s disease (AD) is a common, progressive, and devastating neurodegenerative disorder that mainly affects the elderly. Microglial dysregulation, amyloid-beta (Aβ) plaques, and intracellular neurofibrillary tangles play crucial roles in the pathogenesis of AD. In the… read more here.
Keywords: microglia alzheimer; targeting microglia; alzheimer disease; brain ... See more keywords