The interplay between glioblastoma and microglia cells leads to endothelial cell monolayer dysfunction via the interleukin‐6‐induced JAK2/STAT3 pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28575
Abstract: Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor, with an average life expectancy of 12–15 months. GBM is highly infiltrated by microglial cells (MG) promoting tumor growth and invasiveness. Moreover, microglia… read more here.
Keywords: interplay glioblastoma; glioblastoma; dysfunction; microglia cells ... See more keywords
Scutellarin alleviates blood‐retina‐barrier oxidative stress injury initiated by activated microglia cells during the development of diabetic retinopathy
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2018.11.011
Abstract: &NA; The breakdown of blood‐retinal barrier (BRB) is an early and typical event during the development of diabetic retinopathy (DR). Scutellarin (SC) is a natural flavonoid. This study aims to investigate the protection of SC… read more here.
Keywords: microglia cells; stress injury; development; oxidative stress ... See more keywords
Aflatoxin B1 induces microglia cells apoptosis mediated by oxidative stress through NF-κB signaling pathway in mice spinal cords.
Sign Up to like & getrecommendations! Published in 2021 at "Environmental toxicology and pharmacology"
DOI: 10.1016/j.etap.2021.103794
Abstract: Many studies have shown that aflatoxin B1 (AFB1) can cause cytotoxicity in numerous cells and organs induced by oxidative stress. However, the toxic effects and related mechanism of AFB1 on the microglia cells in the… read more here.
Keywords: oxidative stress; induces microglia; microglia cells; spinal cords ... See more keywords
Modulation of NF-kB signaling by mercury compounds in mouse microglia cells and its relationship with glutathione levels
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.04.275
Abstract: Mercury (Hg) is widely known by its neurotoxicity albeit immunotoxicity occurs at lower exposure levels. Since microglia cells are the major representatives of the immune system in the CNS, we hypothesize Hg compounds disrupt microglia… read more here.
Keywords: mouse microglia; p50 p65; microglia cells; modulation signaling ... See more keywords
Esculentoside A exerts anti‐inflammatory activity in microglial cells
Sign Up to like & getrecommendations! Published in 2017 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2017.08.014
Abstract: Abstract Esculentoside A (EsA) is a saponin isolated from the roots of Phytolacca esculenta. This study was designed to evaluate the pharmacological effects of EsA on lipopolysaccharide (LPS)‐stimulated BV2 microglia and primary microglia cells. Our… read more here.
Keywords: anti inflammatory; primary microglia; bgr; esculentoside exerts ... See more keywords
Oxymatrine exhibits anti-neuroinflammatory effects on Aβ1-42-induced primary microglia cells by inhibiting NF-κB and MAPK signaling pathways.
Sign Up to like & getrecommendations! Published in 2019 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2019.105686
Abstract: Oxymatrine (OMT), isolated from Sophora flavescens or Sophora alopecuroides, possesses various pharmacological and biological activities, including anti-inflammatory, anti-oxidant, and anti-diabetic properties. Microglia cells, the resident immune cells in the central nervous system (CNS), play a… read more here.
Keywords: primary microglia; exhibits anti; microglia cells; neuroinflammatory effects ... See more keywords
CSB6B prevents β-amyloid-associated neuroinflammation and cognitive impairments via inhibiting NF-κB and NLRP3 in microglia cells.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.106263
Abstract: Pathological β-amyloid (Aβ)-induced microglial activation could cause chronic neuroinflammation in the brain of Alzheimer's disease (AD) patients, and has been considered as one of the main pathological events of this disease. Chicago sky blue 6B… read more here.
Keywords: cognitive impairments; inhibiting nlrp3; neuroinflammation; csb6b prevents ... See more keywords
Açaí (Euterpe oleracea Mart.) presents anti-neuroinflammatory capacity in LPS-activated microglia cells.
Sign Up to like & getrecommendations! Published in 2020 at "Nutritional neuroscience"
DOI: 10.1080/1028415x.2020.1842044
Abstract: INTRODUCTION Neuropsychiatric diseases are responsible for one of the highest burden of morbidity and mortality worldwide. These illnesses include schizophrenia, bipolar disorder, and major depression. Individuals affected by these diseases may present mitochondrial dysfunction and… read more here.
Keywords: anti neuroinflammatory; microglia cells; lps activated; cell cycle ... See more keywords
Longxuetongluo capsule alleviates LPS-induced neuro-inflammation by regulating multiple signaling pathways in BV2 microglia cells.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the Chinese Medical Association"
DOI: 10.1097/jcma.0000000000000258
Abstract: BACKGROUND Longxuetongluo capsule (LTC), derived from the total phenolic compounds of Chinese dragon's blood, is now used to treatment of ischemic stroke in convalescence. The aim of this study is to explore the neuroprotective effect… read more here.
Keywords: microglia cells; longxuetongluo capsule; bv2 microglia; signaling pathways ... See more keywords
Cannabidiol affects circadian clock core complex and its regulation in microglia cells
Sign Up to like & getrecommendations! Published in 2018 at "Addiction Biology"
DOI: 10.1111/adb.12660
Abstract: Cannabis is often used by consumers for sleep disorders. Studies show that circadian rhythm could be affected by a misuse of cannabis. Recent research has connected the role of microglial cells with psychiatric disorders such… read more here.
Keywords: light dark; circadian rhythm; microglia cells; microglial cells ... See more keywords
Construction of a 3D brain extracellular matrix model to study the interaction between microglia and T cells in co‐culture
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Neuroscience"
DOI: 10.1111/ejn.14978
Abstract: Neurodegenerative disorders are characterised by the activation of brain‐resident microglia cells and by the infiltration of peripheral T cells. However, their interplay in disease has not been clarified yet. It is difficult to investigate complex… read more here.
Keywords: extracellular matrix; microglia cells; interaction; culture ... See more keywords