Microglia Activate Early Antiviral Responses upon Herpes Simplex Virus 1 Entry into the Brain to Counteract Development of Encephalitis-Like Disease in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.01311-21
Abstract: One of the most devastating and acute neurological conditions is encephalitis, i.e., inflammation of brain tissue. Herpes simplex virus 1 (HSV1) is a highly prevalent pathogen in humans, and the most frequent cause of viral… read more here.
Keywords: hsv1; microglia depletion; brain; encephalitis ... See more keywords
Microglia depletion fails to abrogate inflammation-induced sickness in mice and rats
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-020-01832-2
Abstract: Background Production of inflammatory mediators by reactive microglial cells in the brain is generally considered the primary mechanism underlying the development of symptoms of sickness in response to systemic inflammation. Methods Depletion of microglia was… read more here.
Keywords: mice rats; inflammation; induced sickness; microglia depletion ... See more keywords
An updated assessment of microglia depletion: current concepts and future directions
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Brain"
DOI: 10.1186/s13041-017-0307-x
Abstract: Microglia are the principal resident immune cells in the central nervous system and are believed to be versatile players in both inflammatory and physiological contexts. On the one hand, in order to safeguard the microenvironment… read more here.
Keywords: current concepts; assessment microglia; depletion current; microglia depletion ... See more keywords