Expression of the transcription factor PU.1 induces the generation of microglia-like cells in human cortical organoids
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-022-28043-y
Abstract: Microglia play a role in the emergence and preservation of a healthy brain microenvironment. Dysfunction of microglia has been associated with neurodevelopmental and neurodegenerative disorders. Investigating the function of human microglia in health and disease… read more here.
Keywords: transcription factor; cortical organoids; expression; human cortical ... See more keywords
Fibromyalgia and microglial TNF-α: Translational research using human blood induced microglia-like cells
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-11506-4
Abstract: Fibromyalgia is a refractory disease characterized by chronic intractable pain and psychological suffering, the cause of which has not yet been elucidated due to its complex pathology. Activation of immune cells in the brain called… read more here.
Keywords: using human; research using; img cells; pathology ... See more keywords
Functional analysis of CX3CR1 in human induced pluripotent stem (iPS) cell‐derived microglia‐like cells
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Neuroscience"
DOI: 10.1111/ejn.14879
Abstract: Microglia are the primary immune cells of the central nervous system and crucial to proper development and maintenance of the brain. Microglia have been recognized to be associated with neurodegenerative diseases and neuroinflammatory disorders. CX3C… read more here.
Keywords: cx3cr1 human; cell derived; like cells; ips cell ... See more keywords
Incorporating microglia‐like cells in human induced pluripotent stem cell‐derived retinal organoids
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17670
Abstract: Microglia are the primary resident immune cells in the retina. They regulate neuronal survival and synaptic pruning making them essential for normal development. Following injury, they mediate adaptive responses and under pathological conditions they can… read more here.
Keywords: pluripotent stem; microglia like; retinal organoids; induced pluripotent ... See more keywords
MicroRNA-101a regulates microglial morphology and inflammation
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-017-0884-8
Abstract: BackgroundMicroglia, as well as other tissue-resident macrophages, arise from yolk sac progenitors. Thus, it is likely that the central nervous system environment is critical for the acquisition of a distinct microglial phenotype. Several microRNAs that… read more here.
Keywords: like cells; mir; mir 101a; brain ... See more keywords
Single-cell transcriptomics of the ventral posterolateral nucleus-enriched thalamic regions from HSV-1-infected mice reveal a novel microglia/microglia-like transcriptional response
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-022-02437-7
Abstract: Background Microglia participate in the immune response upon central nervous system (CNS) infections. However, the role of these cells during herpes simplex encephalitis (HSE) has not been fully characterized. We sought to identify different microglia/microglia-like… read more here.
Keywords: like cells; microglia like; microglia microglia; cell ... See more keywords
Microglia and Microglia-Like Cells: Similar but Different
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.816439
Abstract: Microglia are the tissue-resident macrophages of the central nervous parenchyma. In mammals, microglia are thought to originate from yolk sac precursors and posteriorly maintained through the entire life of the organism. However, the contribution of… read more here.
Keywords: similar different; origin; cells similar; microglia microglia ... See more keywords
Detection and Functional Evaluation of the P2X7 Receptor in hiPSC Derived Neurons and Microglia-Like Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2021.793769
Abstract: A large body of evidence suggests the involvement of the ATP-gated purinergic receptor P2X7 (P2X7R) in neurodegenerative diseases, including Alzheimer’s disease. While it is well-described to be present and functional on microglia cells contributing to… read more here.
Keywords: hipsc derived; microglia like; neuronal cells; like cells ... See more keywords
Patient-specific monocyte-derived microglia as a screening tool for neurodegenerative diseases
Sign Up to like & getrecommendations! Published in 2022 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.355740
Abstract: Microglia, the main driver of neuroinflammation, play a central role in the initiation and exacerbation of various neurodegenerative diseases and are now considered a promising therapeutic target. Previous studies on in vitro human microglia and… read more here.
Keywords: patient specific; derived microglia; monocyte derived; microglia like ... See more keywords