Elucidating tumour‐associated microglia/macrophage diversity along glioblastoma progression and under ACOD1 deficiency
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13287
Abstract: In glioblastoma (GBM), tumour‐associated microglia/macrophages (TAMs) represent the major cell type of the stromal compartment and contribute to tumour immune escape mechanisms. Thus, targeting TAMs is emerging as a promising strategy for immunotherapy. However, TAM… read more here.
Keywords: associated microglia; microglia macrophage; progression; tumour ... See more keywords
Molecular profiling of the tumor microenvironment in glioblastoma patients: correlation of microglia/macrophage polarization state with metalloprotease expression profiles and survival
Sign Up to like & getrecommendations! Published in 2019 at "Bioscience Reports"
DOI: 10.1042/bsr20182361
Abstract: Due to poor prognosis of glioblastoma (GBM), there is an urgent need to develop new therapeutic strategies. Besides eliminating GBM tumor cells and stem cells, a novel therapeutic approach aims to target Glioma-associated microglia/macrophages (GAMs).… read more here.
Keywords: expression; microglia macrophage; tumor microenvironment; gbm ... See more keywords
Single Cortical Microinfarcts Lead to Widespread Microglia/Macrophage Migration Along the White Matter.
Sign Up to like & getrecommendations! Published in 2020 at "Cerebral cortex"
DOI: 10.1093/cercor/bhaa223
Abstract: Loss of cognitive function with aging is a complex and poorly understood process. Recently, clinical research has linked the occurrence of cortical microinfarcts to cognitive decline. Cortical microinfarcts form following the occlusion of penetrating vessels… read more here.
Keywords: microglia macrophage; microinfarcts lead; cortical microinfarcts; single cortical ... See more keywords
Distribution and prognostic impact of microglia/macrophage subpopulations in gliomas
Sign Up to like & getrecommendations! Published in 2018 at "Brain Pathology"
DOI: 10.1111/bpa.12690
Abstract: While the central nervous system is considered an immunoprivileged site and brain tumors display immunosuppressive features, both innate and adaptive immune responses affect glioblastoma (GBM) growth and treatment resistance. However, the impact of the major… read more here.
Keywords: macrophage subpopulations; distribution prognostic; microglia macrophage; impact microglia ... See more keywords
STAT6/Arg1 promotes microglia/macrophage efferocytosis and inflammation resolution in stroke mice.
Sign Up to like & getrecommendations! Published in 2019 at "JCI insight"
DOI: 10.1172/jci.insight.131355
Abstract: Efferocytosis, or phagocytic clearance of dead/dying cells by brain-resident microglia and/or infiltrating macrophages, is instrumental for inflammation resolution and restoration of brain homeostasis after stroke. Here, we identify the signal transducer and activator of transcription… read more here.
Keywords: microglia macrophage; arg1; inflammation resolution; stat6 arg1 ... See more keywords
Annexin A1 protects against cerebral ischemia–reperfusion injury by modulating microglia/macrophage polarization via FPR2/ALX-dependent AMPK-mTOR pathway
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-021-02174-3
Abstract: Background Cerebral ischemia–reperfusion (I/R) injury is a major cause of early complications and unfavorable outcomes after endovascular thrombectomy (EVT) therapy in patients with acute ischemic stroke (AIS). Recent studies indicate that modulating microglia/macrophage polarization and… read more here.
Keywords: macrophage polarization; microglia macrophage; polarization; reperfusion ... See more keywords
Meisoindigo Protects Against Focal Cerebral Ischemia-Reperfusion Injury by Inhibiting NLRP3 Inflammasome Activation and Regulating Microglia/Macrophage Polarization via TLR4/NF-κB Signaling Pathway
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2019.00553
Abstract: Ischemic stroke is a devastating disease with long-term disability. However, the pathogenesis is unclear and treatments are limited. Meisoindigo, a second-generation derivative of indirubin, has general water solubility and is well-tolerated. Previous studies have shown… read more here.
Keywords: microglia macrophage; signaling pathway; activation; tlr4 ... See more keywords
Dexmedetomidine post-conditioning protects blood-brain barrier integrity by modulating microglia/macrophage polarization via inhibiting NF-κB signaling pathway in intracerebral hemorrhage
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.977941
Abstract: Intracerebral hemorrhage (ICH) is one of the most devastating forms of stroke. Dexmedetomidine (DEX) has shown certain neuroprotective roles in ICH. Nevertheless, the details concerning the underlying molecular mechanism of DEX’s protective effects still need… read more here.
Keywords: dex; microglia macrophage; macrophage polarization; signaling pathway ... See more keywords