A Virus-Mimicking Nucleic Acid Nanogel Reprograms Microglia and Macrophages for Glioblastoma Therapy.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced materials"
DOI: 10.1002/adma.202006116
Abstract: Immunotherapy is recognized as one of the most promising approaches to treat cancers. However, its effect in glioblastoma (GBM) treatment is insufficient, which can in part be attributed to the immunosuppressive tumor microenvironment (TME). Microglia… read more here.
Keywords: nucleic acid; virus mimicking; microglia macrophages; acid nanogel ... See more keywords
VEGF as a modulator of the innate immune response in glioblastoma
Sign Up to like & getrecommendations! Published in 2018 at "Glia"
DOI: 10.1002/glia.23234
Abstract: VEGF is an important factor in tumor vascularization and used as target for anti‐angiogenic treatment strategies in glioma. In this study, we demonstrate for the first time that VEGF is a modulator of the innate… read more here.
Keywords: microglia macrophages; innate immune; vegf; immune response ... See more keywords
Deletion of the RNA regulator HuR in tumor‐associated microglia and macrophages stimulates anti‐tumor immunity and attenuates glioma growth
Sign Up to like & getrecommendations! Published in 2019 at "Glia"
DOI: 10.1002/glia.23696
Abstract: Glioblastoma is a malignant brain tumor that portends a poor prognosis. Its resilience, in part, is related to a remarkable capacity for manipulating the microenvironment to promote its growth and survival. Microglia/macrophages are prime targets,… read more here.
Keywords: tumor associated; hur; rna regulator; microglia macrophages ... See more keywords
Role of Infiltrating Microglia/Macrophages in Glioma.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-30651-9_14
Abstract: In this chapter we describe the state of the art knowledge of the role played by myeloid cells in promoting and supporting the growth and the invasive properties of a deadly brain tumor, glioblastoma. We… read more here.
Keywords: macrophages glioma; biology; role; role infiltrating ... See more keywords
Microglia and macrophages differ in their inflammatory profile after permanent brain ischemia
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2017.08.011
Abstract: ABSTRACT We studied the expression of pro‐ and anti‐inflammatory molecules in microglia and infiltrating monocyte‐derived macrophages after permanent Middle Cerebral Artery Occlusion (pMCAO). LysM‐EGFP knock‐in mice were used to distinguish between these two cell types,… read more here.
Keywords: inflammatory; expression; ischemia; microglia macrophages ... See more keywords
Activation of microglia and macrophages in the circumventricular organs of the mouse brain during TLR2-induced fever and sickness responses
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuroimmunology"
DOI: 10.1016/j.jneuroim.2019.576973
Abstract: Toll-like receptor 2 (TLR2) recognizes cell wall components from Gram-positive bacteria. Until now, however, little has been known about the significance of brain TLR2 in controlling inflammation and thermoregulatory responses during systemic Gram-positive bacterial infection.… read more here.
Keywords: microglia macrophages; brain tlr2; induced fever; tlr2 ... See more keywords
TSPO ligand Ro5-4864 modulates microglia/macrophages polarization after subarachnoid hemorrhage in mice
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2020.134977
Abstract: Brain injury after subarachnoid hemorrhage (SAH) is closely related to microglia/macrophages-induced neuroinflammation. Translocator protein (TSPO) is a hall marker of activated microglia/macrophages, and the TSPO ligands have been proved to be beneficial for controlling neuroinflammation.… read more here.
Keywords: macrophages polarization; ro5 4864; subarachnoid hemorrhage; tspo ligand ... See more keywords
NIMA-related kinase 7 amplifies NLRP3 inflammasome pro-inflammatory signaling in microglia/macrophages and mice models of spinal cord injury.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2020.112418
Abstract: BACKGROUND NIMA-related kinase-7 (NEK7) is a serine/threonine kinase that drives cell-cycle dynamics by modulating mitotic spindle formation and cytokinesis. It is also a crucial modulator of the pro-inflammatory effects of NOD-like receptor 3 (NLRP3) inflammasome.… read more here.
Keywords: kinase; nlrp3 inflammasome; microglia macrophages; pro inflammatory ... See more keywords
Stroke subtype-dependent synapse elimination by reactive gliosis in mice.
Sign Up to like & getrecommendations! Published in 2021 at "Nature communications"
DOI: 10.1038/s41467-021-27248-x
Abstract: The pathological role of reactive gliosis in CNS repair remains controversial. In this study, using murine ischemic and hemorrhagic stroke models, we demonstrated that microglia/macrophages and astrocytes are differentially involved in engulfing synapses in the… read more here.
Keywords: synapse; reactive gliosis; stroke subtype; gliosis ... See more keywords
Minocycline modulates microglia polarization in ischemia-reperfusion model of retinal degeneration and induces neuroprotection
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DOI: 10.1038/s41598-017-14450-5
Abstract: Retinal ischemia-reperfusion (IR) injury causes irreversible loss of neurons and ultimately leads to permanent visual impairment and blindness. The cellular response under this pathological retinal condition is less clear. Using genetically modified mice, we systematically… read more here.
Keywords: ischemia reperfusion; microglia macrophages; retinal degeneration; polarization ... See more keywords
ASK1 signaling regulates phase-specific glial interactions during neuroinflammation
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2103812119
Abstract: Significance Neuroinflammation is associated with many neurodegenerative diseases such as Alzheimer’s disease and multiple sclerosis (MS). Thus, decreasing neuroinflammation may be a promising treatment for these diseases. Apoptosis signal-related kinase 1 (ASK1) has been shown… read more here.
Keywords: specific ask1; neuroinflammation; ask1 signaling; microglia macrophages ... See more keywords