GPR56 S4 variant is required for microglia‐mediated synaptic pruning
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24293
Abstract: ADGRG1 (also called GPR56) plays critical roles in brain development and wiring, including cortical lamination, central nervous system (CNS) myelination, and developmental synaptic refinement. However, the underlying mechanism(s) in mediating such diverse functions is not… read more here.
Keywords: synaptic pruning; microglia mediated; gpr56 variant; mediated synaptic ... See more keywords
Novel microglia-mediated mechanisms underlying synaptic loss and cognitive impairment after traumatic brain injury
Sign Up to like & getrecommendations! Published in 2021 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2021.08.210
Abstract: Traumatic brain injury (TBI) is one of the leading causes of long-term neurological disability in the world. Currently, there are no therapeutics for treating the deleterious consequences of brain trauma; this is in part due… read more here.
Keywords: traumatic brain; microglia mediated; novel microglia; brain ... See more keywords
Icariin targets Nrf2 signaling to inhibit microglia-mediated neuroinflammation.
Sign Up to like & getrecommendations! Published in 2019 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2019.05.033
Abstract: Microglia-mediated neuroinflammation is an important contributor to the pathogenesis of neurodegenerative diseases. Inhibition of neuroinflammation has been proved to be effective in neurodegenerative diseases treatment. Nuclear factor erythroid 2 related factor 2 (Nrf2) is a… read more here.
Keywords: microglia mediated; neuroinflammation; mediated neuroinflammation; neurodegenerative diseases ... See more keywords
Cornel Iridoid Glycoside Alleviates Microglia-Mediated Inflammatory Response via the NLRP3/Calpain Pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c03851
Abstract: Vascular dementia (VaD) is associated with cerebral hypoperfusion, which results in long-term cognitive impairment and memory loss. Cornel iridoid glycoside (CIG) is the major active constituent isolated from the ripe fruit of Cornus officinalis. Previous… read more here.
Keywords: cig; iridoid glycoside; cornel iridoid; microglia mediated ... See more keywords
Patient-specific models of microglia-mediated engulfment of synapses and neural progenitors
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Psychiatry"
DOI: 10.1038/mp.2016.220
Abstract: &NA; Engulfment of synapses and neural progenitor cells (NPCs) by microglia is critical for the development and maintenance of proper brain circuitry, and has been implicated in neurodevelopmental as well as neurodegenerative disease etiology. We… read more here.
Keywords: patient specific; synapses neural; specific models; engulfment synapses ... See more keywords
Inhibition of leucine-rich repeats and calponin homology domain containing 1 accelerates microglia-mediated neuroinflammation in a rat traumatic spinal cord injury model
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-020-01884-4
Abstract: Background Spinal cord injury (SCI) triggers the primary mechanical injury and secondary inflammation-mediated injury. Neuroinflammation-mediated insult causes secondary and extensive neurological damage after SCI. Microglia play a pivotal role in the initiation and progression of… read more here.
Keywords: sci; microglia mediated; injury; rat ... See more keywords
Paroxetine suppresses reactive microglia-mediated but not lipopolysaccharide-induced inflammatory responses in primary astrocytes
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-020-1712-0
Abstract: Background Astrocytes are the most abundant glial cells in a brain that mediate inflammatory responses and provide trophic support for neurons. We have previously disclosed that paroxetine, a common selective serotonin reuptake inhibitor, ameliorates LPS-induced… read more here.
Keywords: inflammatory responses; lps induced; primary astrocytes; microglia mediated ... See more keywords
Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Cardiovascular Diseases
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s350109
Abstract: Abstract Microglia are tissue-resident macrophages of the central nervous system (CNS). In the CNS, microglia play an important role in the monitoring and intervention of synaptic and neuron-level activities. Interventions targeting microglia have been shown… read more here.
Keywords: mediated neuroinflammation; cardiovascular diseases; neuroinflammation potential; microglia mediated ... See more keywords
Galectin-3 in Microglia-Mediated Neuroinflammation: Implications for Central Nervous System Diseases
Sign Up to like & getrecommendations! Published in 2022 at "Current Neuropharmacology"
DOI: 10.2174/1570159x20666220201094547
Abstract: Microglial activation is one of the common hallmarks shared by various central nervous system (CNS) diseases. Based on surrounding circumstances, activated microglia play either detrimental or neuroprotective effects. Galectin-3 (Gal-3), a group of β-galactoside-binding proteins,… read more here.
Keywords: mediated neuroinflammation; cns diseases; neuroinflammation; central nervous ... See more keywords
Microglia-mediated neuroinflammation and neuroplasticity after stroke
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.980722
Abstract: Stroke remains a major cause of long-term disability and mortality worldwide. The immune system plays an important role in determining the condition of the brain following stroke. As the resident innate immune cells of the… read more here.
Keywords: mediated neuroinflammation; microglia mediated; brain; neuroinflammation neuroplasticity ... See more keywords
Electroacupuncture at Fengchi(GB20) and Yanglingquan(GB34) Ameliorates Paralgesia through Microglia-Mediated Neuroinflammation in a Rat Model of Migraine
Sign Up to like & getrecommendations! Published in 2023 at "Brain Sciences"
DOI: 10.3390/brainsci13040541
Abstract: Background: Multiple studies have suggested that paralgesia (hyperalgesia and cutaneous allodynia) in migraine reflects the activation and sensitisation of the trigeminovascular system (TGVS). In particular, it reflects the second-order and higher nerve centre sensitisation, which… read more here.
Keywords: model migraine; microglia mediated; migraine; rat model ... See more keywords