Astragalin attenuates depression-like behaviors and memory deficits and promotes M2 microglia polarization by regulating IL-4R/JAK1/STAT6 signaling pathway in a murine model of perimenopausal depression.
Sign Up to like & getrecommendations! Published in 2022 at "Psychopharmacology"
DOI: 10.1007/s00213-022-06133-5
Abstract: RATIONALE Neuroinflammation can be alleviated via M2 microglia polarization, which could promote the recovery of perimenopausal depression. Astragalin (AST) possesses anti-neuroinflammatory activity. However, the effects of AST on perimenopausal depression and the molecular mechanism in… read more here.
Keywords: model; depression; microglia polarization; perimenopausal depression ... See more keywords
Microglia polarization by methylprednizolone acetate accelerates cuprizone induced demyelination
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Histology"
DOI: 10.1007/s10735-018-9786-z
Abstract: Glucocorticoids (GC) are known as inflammatory drugs, which are used in neuroinflammatory diseases. Unlike the classic picture, recent studies have revealed that some GC drugs exacerbate inflammatory responses in their acute and prolonged administration. Multiple… read more here.
Keywords: induced demyelination; demyelination; cuprizone; cpz ... See more keywords
Unsaponifiable and phenolic fractions from virgin olive oil prevent neuroinflammation skewing microglia polarization toward M2 phenotype
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2019.103543
Abstract: Abstract Inhibiting M1 microglia phenotype while stimulating M2 microglia phenotype has been suggested as potential therapeutic approach for the treatment of neuroinflammation-related diseases. Our aim was to evaluate the anti-neuroinflammatory effects of minor compounds found… read more here.
Keywords: phenotype; neuroinflammation; virgin olive; microglia polarization ... See more keywords
Nomilin Alleviates Neuroinflammation and Depressive-like Behaviors in Mice through the Upregulation of TAX1BP1-Mediated Modulation of Microglia Polarization.
Sign Up to like & getrecommendations! Published in 2025 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.5c00398
Abstract: Nomilin is a limonoid compound that is found in citrus fruits. However, their functions remain to be further studied. The present study mainly analyzed the antineuroinflammation and antidepressive function of nomilin. The antidepressant and antineuroinflammatory… read more here.
Keywords: tax1bp1; nomilin alleviates; upregulation tax1bp1; microglia polarization ... See more keywords
Bioactive polypeptide improves neuroinflammation by regulating microglia polarization
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17059
Abstract: Tolllike receptor (TLR) was first discovered during a research of embryonic development in Drosophila.1 As a class of natural immune receptors, TLRs can identify pathogenassociated molecular patterns (PAMP)2 to initiate relevant signalling pathways, which play… read more here.
Keywords: regulating microglia; bioactive polypeptide; microglia polarization; polypeptide improves ... See more keywords
P2X7 receptor induces microglia polarization to the M1 phenotype in cancer-induced bone pain rat models
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Pain"
DOI: 10.1177/17448069211060962
Abstract: Background The transition from pro-inflammatory M1 phenotype to anti-inflammatory M2 phenotype presents a novel therapeutic strategy for chronic pain. Objective We investigated the role of microglia polarization in cancer-induced bone pain (CIBP), as well as… read more here.
Keywords: p2x7 receptor; pain; microglia polarization; cancer ... See more keywords
Compound 7 regulates microglia polarization and attenuates radiation-induced myelopathy via the Nrf2 signaling pathway in vivo and in vitro studies
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Medicine"
DOI: 10.1186/s10020-024-00951-3
Abstract: Radiation-induced myelopathy (RM) is a significant complication of radiotherapy with its mechanisms still not fully understood and lacking effective treatments. Compound 7 (C7) is a newly identified, potent, and selective inhibitor of the Keap1-Nrf2 interaction.… read more here.
Keywords: radiation; radiation induced; nrf2 signaling; induced myelopathy ... See more keywords
Procaine Regulates the STAT3/CCL5 Axis and Inhibits Microglia M1 Polarization to Alleviate Complete Freund’s Adjuvant Rats Pain Behavior
Sign Up to like & getrecommendations! Published in 2024 at "eNeuro"
DOI: 10.1523/eneuro.0303-24.2024
Abstract: Neuropathic pain (NP) caused by sciatic nerve injury can significantly impact the quality of life of patients. The M1 phenotype of microglia has been reported to promote the progression of NP. Procaine is a lipid-soluble… read more here.
Keywords: ccl5 axis; procaine; microglia polarization; polarization ... See more keywords
A richer and more diverse future for microglia phenotypes.
Sign Up to like & getrecommendations! Published in 2023 at "Heliyon"
DOI: 10.2139/ssrn.4258658
Abstract: Microglia are the only resident innate immune cells derived from the mesoderm in the nerve tissue. They play a role in the development and maturation of the central nervous system (CNS). Microglia mediate the repair… read more here.
Keywords: state; microglia polarization; diverse future; polarization ... See more keywords
Müller Cells Harboring Exosomal lncRNA OGRU Modulate Microglia Polarization in Diabetic Retinopathy by Serving as miRNA Sponges
Sign Up to like & getrecommendations! Published in 2024 at "Diabetes"
DOI: 10.2337/db23-1015
Abstract: Diabetic retinopathy (DR) is one of the most common complications of diabetes worldwide and is associated with visual loss and blindness. However, effective treatments for both early- and late-stage DR remain lacking. A streptozotocin-induced diabetic… read more here.
Keywords: polarization; ogru mir; microglia polarization; diabetic retinopathy ... See more keywords
ALKBH5-Mediated m6A Modification of A20 Regulates Microglia Polarization in Diabetic Retinopathy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.813979
Abstract: Background To investigate the role of microglia polarization in the pathogenesis of diabetic retinopathy, and study the mechanism of ALKBH5-mediated m6A modification of A20 of retinal microglia polarization. Methods Diabetics rats were constructed and the… read more here.
Keywords: m6a modification; a20; microglia polarization; polarization ... See more keywords