Astragalin attenuates depression-like behaviors and memory deficits and promotes M2 microglia polarization by regulating IL-4R/JAK1/STAT6 signaling pathway in a murine model of perimenopausal depression.
Sign Up to like & getrecommendations! Published in 2022 at "Psychopharmacology"
DOI: 10.1007/s00213-022-06133-5
Abstract: RATIONALE Neuroinflammation can be alleviated via M2 microglia polarization, which could promote the recovery of perimenopausal depression. Astragalin (AST) possesses anti-neuroinflammatory activity. However, the effects of AST on perimenopausal depression and the molecular mechanism in… read more here.
Keywords: model; depression; microglia polarization; perimenopausal depression ... See more keywords
Microglia polarization by methylprednizolone acetate accelerates cuprizone induced demyelination
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Histology"
DOI: 10.1007/s10735-018-9786-z
Abstract: Glucocorticoids (GC) are known as inflammatory drugs, which are used in neuroinflammatory diseases. Unlike the classic picture, recent studies have revealed that some GC drugs exacerbate inflammatory responses in their acute and prolonged administration. Multiple… read more here.
Keywords: induced demyelination; demyelination; cuprizone; cpz ... See more keywords
Unsaponifiable and phenolic fractions from virgin olive oil prevent neuroinflammation skewing microglia polarization toward M2 phenotype
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2019.103543
Abstract: Abstract Inhibiting M1 microglia phenotype while stimulating M2 microglia phenotype has been suggested as potential therapeutic approach for the treatment of neuroinflammation-related diseases. Our aim was to evaluate the anti-neuroinflammatory effects of minor compounds found… read more here.
Keywords: phenotype; neuroinflammation; virgin olive; microglia polarization ... See more keywords
Bioactive polypeptide improves neuroinflammation by regulating microglia polarization
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17059
Abstract: Tolllike receptor (TLR) was first discovered during a research of embryonic development in Drosophila.1 As a class of natural immune receptors, TLRs can identify pathogenassociated molecular patterns (PAMP)2 to initiate relevant signalling pathways, which play… read more here.
Keywords: regulating microglia; bioactive polypeptide; microglia polarization; polypeptide improves ... See more keywords
P2X7 receptor induces microglia polarization to the M1 phenotype in cancer-induced bone pain rat models
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Pain"
DOI: 10.1177/17448069211060962
Abstract: Background The transition from pro-inflammatory M1 phenotype to anti-inflammatory M2 phenotype presents a novel therapeutic strategy for chronic pain. Objective We investigated the role of microglia polarization in cancer-induced bone pain (CIBP), as well as… read more here.
Keywords: p2x7 receptor; pain; microglia polarization; cancer ... See more keywords
A richer and more diverse future for microglia phenotypes.
Sign Up to like & getrecommendations! Published in 2023 at "Heliyon"
DOI: 10.2139/ssrn.4258658
Abstract: Microglia are the only resident innate immune cells derived from the mesoderm in the nerve tissue. They play a role in the development and maturation of the central nervous system (CNS). Microglia mediate the repair… read more here.
Keywords: state; microglia polarization; diverse future; polarization ... See more keywords
ALKBH5-Mediated m6A Modification of A20 Regulates Microglia Polarization in Diabetic Retinopathy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.813979
Abstract: Background To investigate the role of microglia polarization in the pathogenesis of diabetic retinopathy, and study the mechanism of ALKBH5-mediated m6A modification of A20 of retinal microglia polarization. Methods Diabetics rats were constructed and the… read more here.
Keywords: m6a modification; a20; microglia polarization; polarization ... See more keywords
Fine-tuning of microglia polarization prevents diabetes-associated cerebral atherosclerosis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.948457
Abstract: Diabetes increases the occurrence and severity of atherosclerosis. When plaques form in brain vessels, cerebral atherosclerosis causes thickness, rigidity, and unstableness of cerebral artery walls, leading to severe complications like stroke and contributing to cognitive… read more here.
Keywords: associated cerebral; diabetes associated; microglia polarization; atherosclerosis ... See more keywords
Sestrin2 provides cerebral protection through activation of Nrf2 signaling in microglia following subarachnoid hemorrhage
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1089576
Abstract: Subarachnoid hemorrhage (SAH) is a neurological emergency characterized by dysfunctional inflammatory response. However, no effective therapeutic options have been reported so far. Microglia polarization has been proposed to exert an essential role in modulating inflammatory… read more here.
Keywords: subarachnoid hemorrhage; microglia polarization; nrf2 signaling; sestrin2 ... See more keywords
Microglia Polarization From M1 to M2 in Neurodegenerative Diseases
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.815347
Abstract: Microglia-mediated neuroinflammation is a common feature of neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS). Microglia can be categorized into two opposite types: classical (M1)… read more here.
Keywords: neurodegenerative diseases; microglia polarization; polarization neurodegenerative;
LncRNA, an Emerging Approach for Neurological Diseases Treatment by Regulating Microglia Polarization
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2022.903472
Abstract: Neurological disorders cause untold human disability and death each year. For most neurological disorders, the efficacy of their primary treatment strategies remains suboptimal. Microglia are associated with the development and progression of multiple neurological disorders.… read more here.
Keywords: polarization; microglia polarization; neurological disorders; regulation ... See more keywords