Microglial Activation and Connectivity in Alzheimer Disease and Aging
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Neurology"
DOI: 10.1002/ana.26465
Abstract: Alzheimer disease (AD) is characterized by amyloid β (Aβ) plaques and neurofibrillary tau tangles, but increasing evidence suggests that neuroinflammation also plays a key role, driven by the activation of microglia. Aβ and tau pathology… read more here.
Keywords: activation connectivity; alzheimer disease; microglial activation; activation ... See more keywords
The glycolytic shift was involved in CdTe/ZnS quantum dots inducing microglial activation mediated through the mTOR signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.3912
Abstract: The excellent optical property and relatively low toxicity of CdTe/ZnS core/shell quantum dots (QDs) make them an advanced fluorescent probe in the application of biomedicines, particularly in neuroscience. Thus, it is important to evaluate the… read more here.
Keywords: shift; zns qds; zns; cdte zns ... See more keywords
Morphine‐mediated release of miR‐138 in astrocyte‐derived extracellular vesicles promotes microglial activation
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12027
Abstract: Abstract Opioids, such as morphine, are the mainstay for the management of postsurgical pain. Over the last decade there has been a dramatic increase in deaths related to opioid overdose. While opioid abuse has been… read more here.
Keywords: extracellular vesicles; mir 138; release mir; activation ... See more keywords
The association of astrogliosis and microglial activation with aging and Alzheimer's disease pathology in the chimpanzee brain
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.25167
Abstract: Aging and neurodegenerative disorders, such as Alzheimer's disease (AD), trigger an immune response known as glial activation in the brain. Recent evidence indicates species differences in inflammatory responses to AD pathology, highlighting the need for… read more here.
Keywords: alzheimer disease; microglial activation; brain; pathology ... See more keywords
Intracerebral Injection of Graphene Oxide Nanosheets Mitigates Microglial Activation Without Inducing Acute Neurotoxicity: A Pilot Comparison to Other Nanomaterials.
Sign Up to like & getrecommendations! Published in 2020 at "Small"
DOI: 10.1002/smll.202004029
Abstract: Carbon-based nanomaterials (CNMs) are being explored for neurological applications. However, systematic in vivo studies investigating the effects of CNM nanocarriers in the brain and how brain cells respond to such nanomaterials are scarce. To address… read more here.
Keywords: graphene oxide; intracerebral injection; injection; brain ... See more keywords
Microglial Activation by Genetically Targeted Conditional Neuronal Ablation in the Zebrafish.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6786-5_26
Abstract: In neurodegenerative diseases activation of immune cells is thought to play a major role. Microglia are the main immune cells of the central nervous system. When encountering disease related stimuli microglia adopt an activated phenotype… read more here.
Keywords: genetically targeted; targeted conditional; activation genetically; conditional neuronal ... See more keywords
The antidepressant effects of asperosaponin VI are mediated by the suppression of microglial activation and reduction of TLR4/NF-κB-induced IDO expression
Sign Up to like & getrecommendations! Published in 2020 at "Psychopharmacology"
DOI: 10.1007/s00213-020-05553-5
Abstract: Aim Indoleamine 2,3-dioxygenase 1 (IDO) is responsible for the progression of the kynurenine pathway, which has been implicated in the pathophysiology of inflammation-induced depression. It has been reported that asperosaponin VI (ASA VI) could play… read more here.
Keywords: ido expression; asa; expression; tlr4 ... See more keywords
Combined 1-Deoxynojirimycin and Ibuprofen Treatment Decreases Microglial Activation, Phagocytosis and Dopaminergic Degeneration in MPTP-Treated Mice
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuroimmune Pharmacology"
DOI: 10.1007/s11481-020-09925-8
Abstract: Inflammation is a predominant aspect of neurodegenerative diseases and experimental studies performed in animal models of Parkinson’s disease (PD) suggesting that a sustained neuroinflammation exacerbates the nigrostriatal degeneration pathway. The central role of microglia in… read more here.
Keywords: treatment; microglial activation; mptp treated; ibuprofen ... See more keywords
PET Evaluation of Microglial Activation in Non-neurodegenerative Brain Diseases
Sign Up to like & getrecommendations! Published in 2019 at "Current Neurology and Neuroscience Reports"
DOI: 10.1007/s11910-019-0951-x
Abstract: Purpose of the ReviewMicroglial cell activation is an important component of neuroinflammation, and it is generally well accepted that chronic microglial activation is indicative of accumulating tissue damage in neurodegenerative conditions, particularly in the earlier… read more here.
Keywords: pet evaluation; evaluation microglial; neuroinflammation; activation ... See more keywords
Microglial Activation Results in Inhibition of TGF-β-Regulated Gene Expression
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-017-0980-3
Abstract: Chronic inflammation mediated by persistent microglial activation is associated with the pathogenesis of neurodegenerative diseases. The mechanisms underlying chronic microglial activation are poorly understood. We have previously shown that anti-inflammatory TGF-β signaling is inhibited in… read more here.
Keywords: tgf regulated; expression; gene expression; microglial activation ... See more keywords
NLRP3 Inflammasome Blockade Reduces Cocaine-Induced Microglial Activation and Neuroinflammation.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular neurobiology"
DOI: 10.1007/s12035-020-02184-x
Abstract: Cocaine use disorder is a major health crisis that is associated with increased oxidative stress and neuroinflammation. While the role of NLRP3 inflammasome in mediating neuroinflammation is well-recognized, whether cocaine induces this response remains unexplored.… read more here.
Keywords: neuroinflammation; cocaine mediated; activation; cocaine ... See more keywords