Impaired autophagy in microglia aggravates dopaminergic neurodegeneration by regulating NLRP3 inflammasome activation in experimental models of Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2021 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2020.10.010
Abstract: Microglia-mediated inflammation plays an important role in the pathogenesis of several neurodegenerative diseases including Parkinson's disease (PD). Recently, autophagy has been linked to the regulation of the inflammatory response. However, the potential role of microglial… read more here.
Keywords: microglial autophagy; neurodegeneration; dopaminergic neurodegeneration; autophagy ... See more keywords
Regulation of α-synuclein homeostasis and inflammasome activation by microglial autophagy
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abn1298
Abstract: Autophagy clears protein aggregates, damaged cellular organelles, and pathogens through the lysosome. Although autophagy is highly conserved across all cell types, its activity in each cell is specifically adapted to carry out distinct physiological functions.… read more here.
Keywords: regulation synuclein; synuclein homeostasis; homeostasis inflammasome; microglial autophagy ... See more keywords
Microglial autophagy in cerebrovascular diseases
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.1023679
Abstract: Microglia are considered core regulators for monitoring homeostasis in the brain and primary responders to central nervous system (CNS) injuries. Autophagy affects the innate immune functions of microglia. Recently some evidence suggests that microglial autophagy… read more here.
Keywords: autophagy cerebrovascular; microglial autophagy; cerebrovascular diseases; autophagy ... See more keywords
The role of microglial autophagy in Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.1039780
Abstract: Parkinson’s disease (PD) is the second most common neurodegenerative disease. Studies have shown that abnormal accumulation of α-synuclein (α-Syn) in the substantia nigra is a specific pathological characteristic of PD. Abnormal accumulation of α-Syn in… read more here.
Keywords: microglial autophagy; parkinson disease; role microglial; autophagy ... See more keywords
Microglial autophagy in Alzheimer’s disease and Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.1065183
Abstract: Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the most common neurodegenerative diseases, characterized by gradual and selective loss of neurons in the central nervous system. They affect more than 50 million people worldwide, and… read more here.
Keywords: disease; alzheimer disease; disease parkinson; parkinson disease ... See more keywords
MicroRNA 223 Targeting ATG16L1 Affects Microglial Autophagy in the Kainic Acid Model of Temporal Lobe Epilepsy
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2021.704550
Abstract: This study aimed to explore whether microRNA (miR) 223 affects microglial autophagy by targeting autophagy-related 16-like 1 (ATG16L1) in the kainic acid (KA) model of temporal lobe epilepsy (TLE). The miRNA and mRNA expression levels… read more here.
Keywords: epilepsy; affects microglial; microglial autophagy; model ... See more keywords