A synthetic diosgenin primary amine derivative attenuates LPS‐stimulated inflammation via inhibition of NF‐&kgr;B and JNK MAPK signaling in microglial BV2 cells
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DOI: 10.1016/j.intimp.2018.05.021
Abstract: &NA; Diosgenin, a precursor of steroid hormones in plants, is known to exhibit diverse pharmacological activities including anti‐inflammatory properties. In this study, (3&bgr;, 25R)‐spirost‐5‐en‐3‐oxyl (2‐((2((2‐aminoethyl)amino)ethyl)amino)ethyl) carbamate (DGP), a new synthetic diosgenin derivative incorporating primary amine… read more here.
Keywords: jnk; lps stimulated; diosgenin; bv2 cells ... See more keywords