Astrocyte‐targeted IL‐10 production decreases proliferation and induces a downregulation of activated microglia/macrophages after PPT
Sign Up to like & getrecommendations! Published in 2019 at "Glia"
DOI: 10.1002/glia.23573
Abstract: When central nervous system (CNS) homeostasis is altered, microglial cells become rapidly activated, proliferate and release a broad range of molecules. Among the plethora of molecules involved in the regulation of microglial activation, cytokines are… read more here.
Keywords: gfap il10tg; production; proliferation; astrocyte targeted ... See more keywords
Microglial expression of GAT‐1 in the cerebral cortex
Sign Up to like & getrecommendations! Published in 2019 at "Glia"
DOI: 10.1002/glia.23745
Abstract: Microglial cells are the immune cells of the brain that, by sensing the microenvironment, permit a correct brain development and function. They communicate with other glial cells and with neurons, releasing and responding to a… read more here.
Keywords: expression gat; microglial expression; expression; gaba uptake ... See more keywords
Piezo1 channel‐mediated Ca2+ signaling inhibits lipopolysaccharide‐induced activation of the NF‐κB inflammatory signaling pathway and generation of TNF‐α and IL‐6 in microglial cells
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24311
Abstract: Microglial cells are crucial in maintaining central nervous system (CNS) homeostasis and mediating CNS disease pathogenesis. Increasing evidence supports that alterations in the mechanical properties of CNS microenvironments influence glial cell phenotypes, but the mechanisms… read more here.
Keywords: activation; microglial cells; piezo1 channel; ca2 signaling ... See more keywords
NADPH oxidase 4 regulate the glycolytic metabolic reprogramming of microglial cells to promote M1 polarization
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23318
Abstract: This work aimed to investigate the role and mechanism of NADPH oxidase 4 (NOX4) in the polarization of microglial cells. Microglial cells were transfected with the NOX4 overexpression plasmid (pGL3‐NOX4), and later treated with lipopolysaccharide… read more here.
Keywords: nadph oxidase; microglial cells; expression; polarization ... See more keywords
Exploitation of microRNAs by Japanese Encephalitis virus in human microglial cells
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DOI: 10.1002/jmv.24995
Abstract: JEV infection in CNS leads to the JE neuroinflammation. Children and old age individual have been reported to be more prone to JEV infection. MicroRNAs are endogenous, small non‐coding RNAs, which regulate the gene expression.… read more here.
Keywords: human microglial; exploitation micrornas; micrornas japanese; japanese encephalitis ... See more keywords
Aurantiamide promotes M2 polarization of microglial cells to improve the cognitive ability of mice with Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7597
Abstract: This work aimed to investigate the effect of aurantiamide (Aur) in promoting the M2 polarization of microglial cells to improve the cognitive ability of mice with Alzheimer's disease (AD). The M2 polarization of BV2 cells… read more here.
Keywords: microglial cells; ability mice; cells improve; polarization microglial ... See more keywords
Isolation and Phenotyping of Adult Mouse Microglial Cells.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7837-3_7
Abstract: Microglia are the resident macrophages of the central nervous system parenchyma and fulfill crucial roles in brain development, homeostasis, and inflammation. The isolation of a pure microglia population from brain tissue enables the examination of… read more here.
Keywords: adult mouse; microglial cells; isolation; brain ... See more keywords
TRPC Channels and Brain Inflammation.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-94-024-1088-4_10
Abstract: Nonresolving low-grade inflammation is supposed to underly the basis of chronic disorders including cardiovascular diseases, cancer, diabetes, obesity, and psychiatric disorders such as depression and Alzheimer's diseases. There is increasing evidence suggesting that pathophysiology of… read more here.
Keywords: channels brain; trpc channels; psychiatric disorders; inflammation ... See more keywords
Changes in neocortical and hippocampal microglial cells during hibernation
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DOI: 10.1007/s00429-017-1596-7
Abstract: Mammalian hibernation proceeds alongside a wide range of complex brain adaptive changes that appear to protect the brain from extreme hypoxia and hypothermia. Using immunofluorescence, confocal microscopy, quantitative analysis methods and intracellular injections, we have… read more here.
Keywords: neocortical hippocampal; hibernation; cells hibernation; changes neocortical ... See more keywords
Role of MSK1 in the Induction of NF-κB by the Chemokine CX3CL1 in Microglial Cells
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-019-00664-w
Abstract: Microglial cells are essential mediators of neuroinflammatory processes involved in several pathologies. Moreover, the chemokine fractalkine (CX3CL1) is essential in the crosstalk between neurons and microglia. However, the exact roles of CX3CL1, CX3CL1 receptor (CX3CR1)… read more here.
Keywords: msk1 induction; cx3cl1; microglial cells; pro inflammatory ... See more keywords
Prolactin Attenuates Neuroinflammation in LPS-Activated SIM-A9 Microglial Cells by Inhibiting NF-κB Pathways Via ERK1/2.
Sign Up to like & getrecommendations! Published in 2021 at "Cellular and molecular neurobiology"
DOI: 10.1007/s10571-021-01087-2
Abstract: Prolactin (PRL) is a pleiotropic hormone with multiple functions in several tissues and organs, including the brain. PRL decreases lesion-induced microgliosis and modifies gene expression related to microglial functions in the hippocampus, thereby providing a… read more here.
Keywords: lps activated; prolactin attenuates; prl; erk1 ... See more keywords