Microglial cGAS Deletion Preserves Intercellular Communication and Alleviates Amyloid‐β‐Induced Pathogenesis of Alzheimer's Disease
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202410910
Abstract: Innate immune activation plays a crucial role in the pathogenesis of Alzheimer's disease (AD) and related dementias (ADRD). The cytosolic DNA sensing pathway, involving cGAMP synthase (cGAS) and Stimulator of Interferon Genes (STING), has emerged… read more here.
Keywords: pathogenesis alzheimer; alzheimer disease; cgas; microglial cgas ... See more keywords
Sesamol alleviates manganese-induced neuroinflammation and cognitive impairment via regulating the microglial cGAS-STING/NF-κB pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Environmental pollution"
DOI: 10.2139/ssrn.4249940
Abstract: Toxic effects of excessive manganese (Mn) from occupational or environmental exposure cause harm to human health. Excessive Mn exposure is intimately associated with neurodegeneration and cognitive dysfunction. Inflammatory responses mediated by microglia are essential contributors… read more here.
Keywords: sesamol; induced neurotoxicity; microglial cgas; sting pathway ... See more keywords