Microglial Dysfunction Mediated by Pb and Amyloid Beta Peptides as a Possible Mechanism of Neurotoxicity
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DOI: 10.1002/jat.4839
Abstract: This study delves into the inflammatory and degenerative impacts of lead (Pb) toxicity and amyloid beta peptides (Aβ‐peptide 1–40 and Aβ‐peptide 25–35) on brain cells, particularly by fostering M1 polarization in microglial cells and subsequent… read more here.
Keywords: dysfunction mediated; microglial dysfunction; amyloid beta; beta peptides ... See more keywords
Lipoprotein-Inspired Nanoscavenger for the Three-Pronged Modulation of Microglia-Derived Neuroinflammation in Alzheimer's Disease Therapy.
Sign Up to like & getrecommendations! Published in 2022 at "Nano letters"
DOI: 10.1021/acs.nanolett.2c00191
Abstract: The inflammatory dysfunction of microglia from excess amyloid-β peptide (Aβ) disposal is an overlooked but pathogenic event in Alzheimer's disease (AD). Here, we exploit a native high-density lipoprotein (HDL)-inspired nanoscavenger (pHDL/Cur-siBACE1) that combines the trinity… read more here.
Keywords: pronged modulation; microglial dysfunction; alzheimer disease; inspired nanoscavenger ... See more keywords