TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function
Sign Up to like & getrecommendations! Published in 2018 at "Neuron"
DOI: 10.1016/j.neuron.2018.01.031
Abstract: Mutations in triggering receptor expressed on myeloid cells 2 (TREM2) have been linked to increased Alzheimer's disease (AD) risk. Neurobiological functions of TREM2 and its pathophysiological ligands remain elusive. Here we found that TREM2 directly… read more here.
Keywords: microglial function; mediates microglial; amyloid mediates; receptor amyloid ... See more keywords
Immunoproteasomes control activation of innate immune signaling and microglial function
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.982786
Abstract: Microglia are the resident immune cells of the central nervous system (CNS) and play a major role in the regulation of brain homeostasis. To maintain their cellular protein homeostasis, microglia express standard proteasomes and immunoproteasomes… read more here.
Keywords: microglial function; stress; function; immune signaling ... See more keywords