The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins
Sign Up to like & getrecommendations! Published in 2019 at "Glia"
DOI: 10.1002/glia.23728
Abstract: Microglial NLRP3 inflammasome activation is emerging as a key contributor to neuroinflammation during neurodegeneration. Pathogenic protein aggregates such as β‐amyloid and α‐synuclein trigger microglial NLRP3 activation, leading to caspase‐1 activation and IL‐1β secretion. Both caspase‐1… read more here.
Keywords: microglial nlrp3; amyotrophic lateral; activation; nlrp3 inflammasome ... See more keywords
Parkin regulates microglial NLRP3 and represses neurodegeneration in Parkinson's disease.
Sign Up to like & getrecommendations! Published in 2023 at "Aging cell"
DOI: 10.1111/acel.13834
Abstract: Microglial hyperactivation of the NOD-, LRR-, and pyrin domain-containing 3 (NLRP3) inflammasome contributes to the pathogenesis of Parkinson's disease (PD). Recently, neuronally expressed NLRP3 was demonstrated to be a Parkin polyubiquitination substrate and a driver… read more here.
Keywords: parkin regulates; parkinson disease; regulates microglial; microglial nlrp3 ... See more keywords