Quantifying Microglial Phagocytosis of Apoptotic Cells in the Brain in Health and Disease
Sign Up to like & getrecommendations! Published in 2018 at "Current Protocols in Immunology"
DOI: 10.1002/cpim.49
Abstract: Apoptosis is a ubiquitous process occurring in the brain under both physiological and pathological conditions. The central nervous system (CNS) requires an active and efficient clean‐up system to prevent the spillover of intracellular contents into… read more here.
Keywords: phagocytosis apoptotic; phagocytosis; apoptotic cells; microglial phagocytosis ... See more keywords
Preliminary analysis of hippocampus synaptic apoptosis and microglial phagocytosis induced by severe restraint stress
Sign Up to like & getrecommendations! Published in 2022 at "Neuropsychopharmacology Reports"
DOI: 10.1002/npr2.12298
Abstract: Several studies reported stress‐induced microglial phagocytosis, but the biochemical mechanisms by which stress alters microglial synaptic phagocytosis are not fully uncovered. Local or limited apoptosis without cell death was observed at neuronal synapses in previous… read more here.
Keywords: stress; severe restraint; synaptic apoptosis; phagocytosis ... See more keywords
Microglial phagocytosis dysfunction in stroke is driven by energy depletion and induction of autophagy.
Sign Up to like & getrecommendations! Published in 2023 at "Autophagy"
DOI: 10.1080/15548627.2023.2165313
Abstract: Microglial phagocytosis of apoptotic debris prevents buildup damage of neighbor neurons and inflammatory responses. Whereas microglia are very competent phagocytes under physiological conditions, we report their dysfunction in mouse and preclinical monkey models of stroke… read more here.
Keywords: phagocytosis; microglial phagocytosis; dysfunction; phagocytosis dysfunction ... See more keywords
P2Y6 receptor‐dependent microglial phagocytosis of synapses mediates synaptic and memory loss in aging
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DOI: 10.1111/acel.13761
Abstract: Aging causes loss of brain synapses and memory, and microglial phagocytosis of synapses may contribute to this loss. Stressed neurons can release the nucleotide UTP, which is rapidly converted into UDP, that in turn activates… read more here.
Keywords: microglial phagocytosis; p2y6 receptor; loss; phagocytosis synapses ... See more keywords
Continued P2X7 activation leads to mitochondrial fission and compromising microglial phagocytosis after subarachnoid haemorrhage
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.15712
Abstract: Subarachnoid haemorrhage (SAH) has a high rate of disability and mortality. Extremely damaging molecules, including adenosine triphosphate (ATP), are released from extravasated red blood cells and nerve cells, which activate microglia and induce sterile tissue… read more here.
Keywords: p2x7 activation; phagocytosis; microglial phagocytosis; mitochondrial fission ... See more keywords
Peli1 impairs microglial Aβ phagocytosis through promoting C/EBPβ degradation
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DOI: 10.1371/journal.pbio.3000837
Abstract: Amyloid-β (Aβ) accumulation in the brain is a hallmark of Alzheimer’s disease (AD) pathology. However, the molecular mechanism controlling microglial Aβ phagocytosis is poorly understood. Here we found that the E3 ubiquitin ligase Pellino 1… read more here.
Keywords: degradation; peli1 impairs; peli1; impairs microglial ... See more keywords
Neu1 Is Released From Activated Microglia, Stimulating Microglial Phagocytosis and Sensitizing Neurons to Glutamate
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.917884
Abstract: Neuraminidase 1 (Neu1) hydrolyses terminal sialic acid residues from glycoproteins and glycolipids, and is normally located in lysosomes, but can be released onto the surface of activated myeloid cells and microglia. We report that endotoxin/lipopolysaccharide-activated… read more here.
Keywords: neuronal death; phagocytosis; microglial phagocytosis; activated microglia ... See more keywords
The TREM2 H157Y Variant Influences Microglial Phagocytosis, Polarization, and Inflammatory Cytokine Release
Sign Up to like & getrecommendations! Published in 2023 at "Brain Sciences"
DOI: 10.3390/brainsci13040642
Abstract: Previously, we reported that H157Y, a rare coding variant on exon 3 of the triggering receptor expressed on myeloid cells 2 gene (TREM2), was associated with Alzheimer’s disease (AD) risk in a Han Chinese population.… read more here.
Keywords: microglial phagocytosis; h157y variant; trem2 h157y;