Modulation of microglial phenotypes improves sepsis-induced hippocampus- dependent cognitive impairments and decreases brain inflammation in an animal model of sepsis.
Sign Up to like & getrecommendations! Published in 2020 at "Clinical science"
DOI: 10.1042/cs20191322
Abstract: BACKGROUND In order to modulate microglial phenotypes in vivo, M1 microglia were depleted by administration of gadolinium chloride and the expression of M2 microglia was induced by IL-4 administration in an animal model of sepsis… read more here.
Keywords: model sepsis; sepsis induced; sepsis; microglial phenotypes ... See more keywords
Pharmacological Modulation of Functional Phenotypes of Microglia in Neurodegenerative Diseases
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2017.00139
Abstract: Microglia are the resident innate immune cells of the central nervous system that mediate brain homeostasis maintenance. Microglia-mediated neuroinflammation is a hallmark shared by various neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis.… read more here.
Keywords: microglial phenotypes; modulation; pharmacological modulation; neurodegenerative diseases ... See more keywords