Spinal microglial M1 polarization contributes paclitaxel‐induced neuropathic pain by triggering cells necroptosis
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23669
Abstract: Paclitaxel (PTX) is a chemotherapeutic agent that is widely used for the treatment of several types of tumors. However, PTX‐induced peripheral neuropathy (PIPN) is an adverse effect generally induced by long‐term PTX use that significantly… read more here.
Keywords: ptx induced; microglial polarization; necroptosis; neuropathic pain ... See more keywords
Intranasal Delivery of Pure Nanodrug Loaded Liposomes for Alzheimer's Disease Treatment by Efficiently Regulating Microglial Polarization.
Sign Up to like & getrecommendations! Published in 2024 at "Small"
DOI: 10.1002/smll.202405781
Abstract: The activated M1-like microglia induced neuroinflammation is the critical pathogenic event in Alzheimer's disease (AD). Microglial polarization from pro-inflammatory M1 toward anti-inflammatory M2 phenotype is a promising strategy. To efficiently accomplish this, amyloid-β (Aβ) aggregates… read more here.
Keywords: alzheimer disease; treatment; microglial polarization; intranasal ... See more keywords
L-3-n-Butylphthalide reduces ischemic stroke injury and increases M2 microglial polarization
Sign Up to like & getrecommendations! Published in 2018 at "Metabolic Brain Disease"
DOI: 10.1007/s11011-018-0307-2
Abstract: Overwhelming evidence suggests that microglia play an important role in ischemic injury and they polarize into two different phenotypes with distinct functions after ischemic stroke. We performed the present study to investigate whether L-3-n butylphthalide… read more here.
Keywords: microglial polarization; ischemic stroke; butylphthalide; days mcao ... See more keywords
The Cannabinoid WIN 55,212-2 Reduces Delayed Neurologic Sequelae After Carbon Monoxide Poisoning by Promoting Microglial M2 Polarization Through ST2 Signaling
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-019-01429-2
Abstract: Delayed neurologic sequelae (DNS) are among the most serious complications of carbon monoxide (CO) poisoning caused partly by elevated neuroinflammation. WIN 55,212-2, a non-selective agonist of cannabinoid receptors, has been demonstrated to have anti-inflammatory properties… read more here.
Keywords: microglial polarization; microglia; win 212; st2 signaling ... See more keywords
The Mycobacterial Adjuvant Analogue TDB Attenuates Neuroinflammation via Mincle-Independent PLC-γ1/PKC/ERK Signaling and Microglial Polarization
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-1135-4
Abstract: Microglial activation has long been recognized as a hallmark of neuroinflammation. Recently, the bacillus Calmette-Guerin (BCG) vaccine has been reported to exert neuroprotective effects against several neurodegenerative disorders. Trehalose-6,6′-dibehenate (TDB) is a synthetic analogue of… read more here.
Keywords: microglial polarization; plc pkc; polarization; tdb ... See more keywords
ERRα Knockout Promotes M2 Microglial Polarization and Inhibits Ferroptosis in Sepsis-Associated Brain Dysfunction
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Neurobiology"
DOI: 10.1007/s12035-025-05005-1
Abstract: Sepsis-associated brain dysfunction (SABD) is a critical neurological complication with high mortality, yet its pathogenesis remains poorly understood. This study investigated the role of estrogen-related receptor α (ERRα) in SABD pathogenesis using ERRα knockout (KO)… read more here.
Keywords: associated brain; microglial polarization; brain dysfunction; err knockout ... See more keywords
DTX1 Modulates Microglial M1 Polarization and Exacerbates Neuroinflammation in Traumatic Brain Injury Model Rats through NF—κB/IRF5
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Neurobiology"
DOI: 10.1007/s12035-025-05200-0
Abstract: Microglial polarization is crucial in the pathogenesis of traumatic brain injury (TBI), yet the underlying regulatory mechanisms remain incompletely understood. In this study, we investigated the role of Deltex E3 ubiquitin ligase 1 (DTX1) in… read more here.
Keywords: traumatic brain; dtx1; microglial polarization; tbi ... See more keywords
Baicalein ameliorates ischemic brain damage through suppressing proinflammatory microglia polarization via inhibiting the TLR4/NF-κB and STAT1 pathway
Sign Up to like & getrecommendations! Published in 2021 at "Brain Research"
DOI: 10.1016/j.brainres.2021.147626
Abstract: Microglial polarization mediated neuroinflammation plays an important role in the pathological process of stroke. The aim of this study is to determine whether baicalein indirectly ameliorates neuronal injury through modulating microglial polarization after stroke and… read more here.
Keywords: microglial polarization; baicalein; polarization; pathway ... See more keywords
Sevoflurane suppresses microglial M2 polarization
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2017.07.001
Abstract: Microglia can be polarized into the classical (M1) or alternative (M2) activation states in response to various stimuli. The M2 phenotype has its own set of receptor profiles, cytokine production, and chemokine secretion, of which… read more here.
Keywords: microglial polarization; microglial activation; sevoflurane suppresses; sevoflurane ... See more keywords
LRP1 activation attenuates white matter injury by modulating microglial polarization through Shc1/PI3K/Akt pathway after subarachnoid hemorrhage in rats
Sign Up to like & getrecommendations! Published in 2019 at "Redox Biology"
DOI: 10.1016/j.redox.2019.101121
Abstract: White matter injury (WMI) is associated with motor deficits and cognitive dysfunctions in subarachnoid hemorrhage (SAH) patients. Therapeutic strategy targeting WMI would likely improve the neurological outcomes after SAH. Low-density lipoprotein receptor-related protein-1 (LRP1), a… read more here.
Keywords: microglial polarization; pi3k; polarization; lrp1 activation ... See more keywords
Dihydrolipoic acid-gold nanoclusters regulate microglial polarization and have the potential to alter neurogenesis.
Sign Up to like & getrecommendations! Published in 2019 at "Nano letters"
DOI: 10.1021/acs.nanolett.9b04216
Abstract: Microglia-mediated neuroinflammation is one of the most significant features in a variety of central nervous system (CNS) disorders such as traumatic brain injury, stroke and many neurodegenerative diseases. Microglia become polarized upon stimulation. The two… read more here.
Keywords: microglial polarization; dihydrolipoic acid; regulate microglial; gold nanoclusters ... See more keywords