Integrin-dependent microgliosis mediates ketamine-induced neuronal apoptosis during postnatal rat retinal development
Sign Up to like & getrecommendations! Published in 2021 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2021.113659
Abstract: PURPOSE Remodeling of the extracellular matrix (ECM) by matrix metalloproteinases (MMPs) plays a pivotal role for microglia in developing retina. We tested whether integrin-dependent microgliosis mediates ketamine-induced neuronal apoptosis in the developing rat retina. METHODS… read more here.
Keywords: induced neuronal; microgliosis; neuronal apoptosis; ketamine induced ... See more keywords
Transcranial photobiomodulation (808 nm) attenuates pentylenetetrazole-induced seizures by suppressing hippocampal neuroinflammation, astrogliosis, and microgliosis in peripubertal rats
Sign Up to like & getrecommendations! Published in 2022 at "Neurophotonics"
DOI: 10.1117/1.nph.9.1.015006
Abstract: Abstract. Significance: Transcranial photobiomodulation (tPBM) at 808 nm attenuates pentylenetetrazole (PTZ)-induced seizures and convulsive status epilepticus (CSE) in peripubertal rats by protecting neurons from injury and parvalbumin-positive interneurons from apoptosis, and preserving the integrity of… read more here.
Keywords: peripubertal rats; astrogliosis; induced seizures; microgliosis ... See more keywords
The potassium channel KCa3.1 represents a valid pharmacological target for microgliosis-induced neuronal impairment in a mouse model of Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-019-1682-2
Abstract: BackgroundRecent studies described a critical role for microglia in Parkinson’s disease (PD), where these central nerve system resident immune cells participate in the neuroinflammatory microenvironment that contributes to dopaminergic neurons loss in the substantia nigra.… read more here.
Keywords: microgliosis; parkinson disease; mouse model; kca3 ... See more keywords
Metformin ameliorates olanzapine-induced obesity and glucose intolerance by regulating hypothalamic inflammation and microglial activation in female mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.906717
Abstract: Olanzapine (OLZ), a widely used second-generation antipsychotic drug, is known to cause metabolic side effects, including diabetes and obesity. Interestingly, OLZ-induced metabolic side effects have been demonstrated to be more profound in females in human… read more here.
Keywords: inflammation; hypothalamic inflammation; microglial activation; glucose intolerance ... See more keywords