Implications of microgravity-induced cell signaling alterations upon cancer cell growth, invasiveness, metastatic potential, and control by host immunity.
Sign Up to like & getrecommendations! Published in 2021 at "International review of cell and molecular biology"
DOI: 10.1016/bs.ircmb.2021.01.004
Abstract: The human endeavor to venture beyond the orbit of Earth is challenged by both continuous space radiation and microgravity-induced immune dysfunction. If cancers were to develop in astronauts, it is unclear how these abnormal cells… read more here.
Keywords: host immunity; growth; microgravity; microgravity induced ... See more keywords
The NATO project: nanoparticle-based countermeasures for microgravity-induced osteoporosis
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-53481-y
Abstract: Recent advances in nanotechnology applied to medicine and regenerative medicine have an enormous and unexploited potential for future space and terrestrial medical applications. The Nanoparticles and Osteoporosis (NATO) project aimed to develop innovative countermeasures for… read more here.
Keywords: medicine; nsr hap; bone; nato project ... See more keywords
Protection of primary cilia is an effective countermeasure against the impairment of osteoblast function induced by simulated microgravity
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17628
Abstract: The molecular mechanism for the microgravity‐induced decrease in bone formation remains unclear and there is a lack of effective specific preventative therapies. We recently reported that primary cilia of osteoblasts became shorter and even disappeared… read more here.
Keywords: microgravity; simulated microgravity; mirna 129; effective countermeasure ... See more keywords
Bioinformatic analysis of the RNA expression patterns in microgravity-induced bone loss
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.985025
Abstract: Researchers have linked microgravity in space to the significant imbalance between bone formation and bone resorption that induces persistent bone loss in load-bearing bones. However, the underlying molecular mechanisms are still unclear, which hinders the… read more here.
Keywords: microgravity; expression; bone loss; microgravity induced ... See more keywords
Antioxidant Strategy to Prevent Simulated Microgravity-Induced Effects on Bone Osteoblasts
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21103638
Abstract: The effects induced by microgravity on human body functions have been widely described, in particular those on skeletal muscle and bone tissues. This study aims to implement information on the possible countermeasures necessary to neutralize… read more here.
Keywords: simulated microgravity; induced effects; bone; induced microgravity ... See more keywords