A new imaging platform (iScreen) allows for the concurrent assessment of micronucleus induction and genotoxic mode of action in human A375 cells
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DOI: 10.1002/em.22496
Abstract: Genotoxicity testing guidelines require the assessment of the clastogenic and aneugenic potential of compounds. While in vitro micronucleus assays detect both types of endpoints, it requires labor‐intensive microscopic scoring and does not discriminate between the… read more here.
Keywords: imaging platform; platform; a375 cells; micronucleus induction ... See more keywords
Comparative analysis of micronucleus induction and DNA damage biomarkers in TK6 and A375 cells using flow cytometry
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DOI: 10.1002/em.22585
Abstract: Previously, we introduced an alternative adherent A375 cell line for clastogenicity and aneugenicity testing using a high content imaging platform. To further characterize the performance of A375 cells, we investigated the sensitivity and specificity of… read more here.
Keywords: a375 cells; using flow; micronucleus induction; cell ... See more keywords