Furin-Guided Intracellular 68Ga Nanoparticle Formation Enhances Tumor MicroPET Imaging.
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DOI: 10.1021/acs.analchem.9b04788
Abstract: Positron-emission tomography (PET) is routinely used in clinic for tumor imaging with ultra high sensitivity but tumor-targeted PET imaging probes are quite few. In this work, we rationally designed a furin-responsive radiotracer Acetyl-Arg-Val-Arg-Arg-Cys(StBu)-Lys(DOTA-68Ga)-CBT (CBT-68Ga) and… read more here.
Keywords: nanoparticle formation; micropet imaging; tumor;