Human iPSC-Derived Proinflammatory Macrophages cause Insulin Resistance in an Isogenic White Adipose Tissue Microphysiological System.
Sign Up to like & getrecommendations! Published in 2023 at "Small"
DOI: 10.1002/smll.202203725
Abstract: Chronic white adipose tissue (WAT) inflammation has been recognized as a critical early event in the pathogenesis of obesity-related disorders. This process is characterized by the increased residency of proinflammatory M1 macrophages in WAT. However,… read more here.
Keywords: microphysiological system; ipsc derived; adipose tissue; white adipose ... See more keywords
Acetaminophen absorption and metabolism in an intestine/liver microphysiological system.
Sign Up to like & getrecommendations! Published in 2019 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2018.11.010
Abstract: This study describes the characterization of pharmacokinetic (PK) properties of acetaminophen (APAP) in the Two-Organ-Chip platform (2-OC), a two-chamber device able to cultivate 3D tissues under flow. The APAP intestinal absorption and hepatic metabolism were… read more here.
Keywords: absorption; intestine; metabolism; microphysiological system ... See more keywords
Microphysiological System Modeling of Ochratoxin A-Associated Nephrotoxicity.
Sign Up to like & getrecommendations! Published in 2020 at "Toxicology"
DOI: 10.1016/j.tox.2020.152582
Abstract: Ochratoxin A (OTA) is one of the most abundant mycotoxin contaminants in food stuffs and possesses carcinogenic, nephrotoxic, teratogenic, and immunotoxic properties. Specifically, a major concern is severe nephrotoxicity, which is characterized by degeneration of… read more here.
Keywords: microphysiological system; toxicity; ota induced; nephrotoxicity ... See more keywords
Innate immune cell response to host-parasite interaction in a human intestinal tissue microphysiological system
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1101/2022.01.27.478058
Abstract: Protozoan parasites that infect humans are widespread, and lead to varied clinical manifestations, including life-threatening illnesses in immunocompromised individuals. Animal models have provided insight into innate immunity against parasitic infections, however, species-specific differences and complexity… read more here.
Keywords: microphysiological system; human intestinal; innate immune; intestinal tissue ... See more keywords
Microphysiological system for studying contractile differences in young, active, and old, sedentary adult derived skeletal muscle cells
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DOI: 10.1111/acel.13650
Abstract: Microphysiological systems (MPS), also referred to as tissue chips, incorporating 3D skeletal myobundles are a novel approach for physiological and pharmacological studies to uncover new medical treatments for sarcopenia. We characterize a MPS in which… read more here.
Keywords: microphysiological system; myobundles derived; skeletal muscle; young active ... See more keywords
Innate immune cell response to host-parasite interaction in a human intestinal tissue microphysiological system.
Sign Up to like & getrecommendations! Published in 2022 at "Science advances"
DOI: 10.1126/sciadv.abm8012
Abstract: Protozoan parasites that infect humans are widespread and lead to varied clinical manifestations, including life-threatening illnesses in immunocompromised individuals. Animal models have provided insight into innate immunity against parasitic infections; however, species-specific differences and complexity… read more here.
Keywords: microphysiological system; system; innate immune; intestinal tissue ... See more keywords