Advanced Materials and Sensors for Microphysiological Systems: Focus on Electronic and Electro-optical Interfaces.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced materials"
DOI: 10.1002/adma.202107876
Abstract: Advanced in vitro cell culture systems or microphysiological systems (MPSs), including microfluidic organ-on-a-chip (OoC), are breakthrough technologies in biomedicine. These systems recapitulate features of human tissues outside of the body. They are increasingly being used to… read more here.
Keywords: systems focus; materials sensors; physiology; sensors microphysiological ... See more keywords
Novel Biomimetic Microphysiological Systems for Tissue Regeneration and Disease Modeling.
Sign Up to like & getrecommendations! Published in 2018 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-0947-2_6
Abstract: Biomaterials engineered to closely mimic morphology, architecture, and nanofeatures of naturally occurring in vivo extracellular matrices (ECM) have gained much interest in regenerative medicine and in vitro biomimetic platforms. Similarly, microphysiological systems (MPS), such as… read more here.
Keywords: medicine; novel biomimetic; biomimetic microphysiological; systems tissue ... See more keywords
Smart Cell Culture Systems: Integration of Sensors and Actuators into Microphysiological Systems.
Sign Up to like & getrecommendations! Published in 2018 at "ACS chemical biology"
DOI: 10.1021/acschembio.7b01029
Abstract: Technological advances in microfabrication techniques in combination with organotypic cell and tissue models have enabled the realization of microphysiological systems capable of recapitulating aspects of human physiology in vitro with great fidelity. Concurrently, a number… read more here.
Keywords: integration sensors; culture systems; cell culture; microphysiological systems ... See more keywords
Inversion and computational maturation of drug response using human stem cell derived cardiomyocytes in microphysiological systems
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-35858-7
Abstract: While cardiomyocytes differentiated from human induced pluripotent stems cells (hiPSCs) hold great promise for drug screening, the electrophysiological properties of these cells can be variable and immature, producing results that are significantly different from their… read more here.
Keywords: inversion computational; computational maturation; drug; microphysiological systems ... See more keywords
Microphysiological systems to study colorectal cancer: state-of-the-art
Sign Up to like & getrecommendations! Published in 2023 at "Biofabrication"
DOI: 10.1088/1758-5090/acc279
Abstract: Basic pre-clinical research based on 2D cultures have been very valuable in colorectal cancer (CRC) research but still have failed to improve patient prognostic outcomes. This is because they simply do not replicate what happens… read more here.
Keywords: state art; microphysiological systems; colorectal cancer; research ... See more keywords
Perspective on the Application of Microphysiological Systems to Drug Transporter Studies
Sign Up to like & getrecommendations! Published in 2018 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.118.082750
Abstract: Transmembrane flux of a drug within a tissue or organ frequently involves a complex system of transporters from multiple families that have redundant and overlapping specificities. Current in vitro systems poorly represent physiology, with reduced… read more here.
Keywords: drug; microphysiological systems; physiology; drug transporter ... See more keywords
Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery.
Sign Up to like & getrecommendations! Published in 2018 at "Annual review of pharmacology and toxicology"
DOI: 10.1146/annurev-pharmtox-010617-052722
Abstract: Enhancing the early detection of new therapies that are likely to carry a safety liability in the context of the intended patient population would provide a major advance in drug discovery. Microphysiological systems (MPS) technology… read more here.
Keywords: safety; drug; application; microphysiological systems ... See more keywords
Human Organ-on-a-Chip Microphysiological Systems to Model Musculoskeletal Pathologies and Accelerate Therapeutic Discovery
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.846230
Abstract: Human Microphysiological Systems (hMPS), otherwise known as organ- and tissue-on-a-chip models, are an emerging technology with the potential to replace in vivo animal studies with in vitro models that emulate human physiology at basic levels.… read more here.
Keywords: therapeutic discovery; musculoskeletal tissues; chip; microphysiological systems ... See more keywords
A Progress Report and Roadmap for Microphysiological Systems and Organ-On-A-Chip Technologies to Be More Predictive Models in Human (Knee) Osteoarthritis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.886360
Abstract: Osteoarthritis (OA), a chronic debilitating joint disease affecting hundreds of million people globally, is associated with significant pain and socioeconomic costs. Current treatment modalities are palliative and unable to stop the progressive degeneration of articular… read more here.
Keywords: report roadmap; roadmap microphysiological; progress; progress report ... See more keywords
Critical Considerations for the Design of Multi-Organ Microphysiological Systems (MPS)
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.721338
Abstract: Identification and approval of new drugs for use in patients requires extensive preclinical studies and clinical trials. Preclinical studies rely on in vitro experiments and animal models of human diseases. The transferability of drug toxicity… read more here.
Keywords: systems mps; drug; microphysiological systems; toxicity ... See more keywords
Microphysiological Systems for Studying Cellular Crosstalk During the Neutrophil Response to Infection
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.661537
Abstract: Neutrophils are the primary responders to infection, rapidly migrating to sites of inflammation and clearing pathogens through a variety of antimicrobial functions. This response is controlled by a complex network of signals produced by vascular… read more here.
Keywords: response; response infection; systems studying; microphysiological systems ... See more keywords