Microphysiological Systems of Lymphatics and Immune Organs.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202503201
Abstract: Microphysiological systems (MPS) that incorporate engineered blood vasculatures have enabled new opportunities to study human physiology and disease, offering platforms for drug development, tissue modeling, and regenerative medicine. However, most human tissues also contain an… read more here.
Keywords: physiology; medicine; immune organs; lymphatics immune ... See more keywords
Advanced Materials and Sensors for Microphysiological Systems: Focus on Electronic and Electro-optical Interfaces.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced materials"
DOI: 10.1002/adma.202107876
Abstract: Advanced in vitro cell culture systems or microphysiological systems (MPSs), including microfluidic organ-on-a-chip (OoC), are breakthrough technologies in biomedicine. These systems recapitulate features of human tissues outside of the body. They are increasingly being used to… read more here.
Keywords: systems focus; materials sensors; physiology; sensors microphysiological ... See more keywords
Novel Biomimetic Microphysiological Systems for Tissue Regeneration and Disease Modeling.
Sign Up to like & getrecommendations! Published in 2018 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-0947-2_6
Abstract: Biomaterials engineered to closely mimic morphology, architecture, and nanofeatures of naturally occurring in vivo extracellular matrices (ECM) have gained much interest in regenerative medicine and in vitro biomimetic platforms. Similarly, microphysiological systems (MPS), such as… read more here.
Keywords: medicine; novel biomimetic; biomimetic microphysiological; systems tissue ... See more keywords
Microphysiological Systems as Organ-Specific In Vitro Vascular Models for Disease Modeling
Sign Up to like & getrecommendations! Published in 2024 at "BioChip Journal"
DOI: 10.1007/s13206-024-00152-4
Abstract: The vascular system, essential for human physiology, is vital for transporting nutrients, oxygen, and waste. Since vascular structures are involved in various disease pathogeneses and exhibit different morphologies depending on the organ, researchers have endeavored… read more here.
Keywords: organ specific; vitro vascular; vascular models; specific vitro ... See more keywords
Smart Cell Culture Systems: Integration of Sensors and Actuators into Microphysiological Systems.
Sign Up to like & getrecommendations! Published in 2018 at "ACS chemical biology"
DOI: 10.1021/acschembio.7b01029
Abstract: Technological advances in microfabrication techniques in combination with organotypic cell and tissue models have enabled the realization of microphysiological systems capable of recapitulating aspects of human physiology in vitro with great fidelity. Concurrently, a number… read more here.
Keywords: integration sensors; culture systems; cell culture; microphysiological systems ... See more keywords
Inversion and computational maturation of drug response using human stem cell derived cardiomyocytes in microphysiological systems
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-35858-7
Abstract: While cardiomyocytes differentiated from human induced pluripotent stems cells (hiPSCs) hold great promise for drug screening, the electrophysiological properties of these cells can be variable and immature, producing results that are significantly different from their… read more here.
Keywords: inversion computational; computational maturation; drug; microphysiological systems ... See more keywords
Microphysiological systems to study colorectal cancer: state-of-the-art
Sign Up to like & getrecommendations! Published in 2023 at "Biofabrication"
DOI: 10.1088/1758-5090/acc279
Abstract: Basic pre-clinical research based on 2D cultures have been very valuable in colorectal cancer (CRC) research but still have failed to improve patient prognostic outcomes. This is because they simply do not replicate what happens… read more here.
Keywords: state art; microphysiological systems; colorectal cancer; research ... See more keywords
Perspective on the Application of Microphysiological Systems to Drug Transporter Studies
Sign Up to like & getrecommendations! Published in 2018 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.118.082750
Abstract: Transmembrane flux of a drug within a tissue or organ frequently involves a complex system of transporters from multiple families that have redundant and overlapping specificities. Current in vitro systems poorly represent physiology, with reduced… read more here.
Keywords: drug; microphysiological systems; physiology; drug transporter ... See more keywords
Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery.
Sign Up to like & getrecommendations! Published in 2018 at "Annual review of pharmacology and toxicology"
DOI: 10.1146/annurev-pharmtox-010617-052722
Abstract: Enhancing the early detection of new therapies that are likely to carry a safety liability in the context of the intended patient population would provide a major advance in drug discovery. Microphysiological systems (MPS) technology… read more here.
Keywords: safety; drug; application; microphysiological systems ... See more keywords
Microphysiological systems to advance human pathophysiology and translational medicine.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of applied physiology"
DOI: 10.1152/japplphysiol.00087.2024
Abstract: Microphysiological systems (MPS) or "organ-on-a-chip" models are sophisticated tools that harness techniques from cell biology, tissue engineering, and microengineering to recapitulate human physiology. Typically, MPS are biofabricated 3-dimensional tissue constructs integrated into platforms designed to… read more here.
Keywords: physiology; systems advance; pathophysiology; medicine ... See more keywords
Leveraging microphysiological systems to expedite understanding of host–parasite interactions
Sign Up to like & getrecommendations! Published in 2025 at "PLOS Pathogens"
DOI: 10.1371/journal.ppat.1013088
Abstract: Microphysiological systems (MPS) replicate the dynamic interactions between cells, tissues, and fluids. They have emerged as transformative tools for biology and have been increasingly applied to host–parasite interactions. Offering a better representation of cellular behavior… read more here.
Keywords: host; host parasite; parasite interactions; parasitic diseases ... See more keywords