An Intelligent Redox‐Responsive DNA Circuit for Robust On‐Site Profiling of Glutathione‐MicroRNA Signaling Pathway
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202315993
Abstract: Synthetic biochemical circuits (e.g., DNA circuits) remain at the forefront of intracellular biosensing tasks yet are hindered by the undesired off‐site activation and the accompanying signal leakage. Herein, the study attempts to overcome this limitation… read more here.
Keywords: dna circuit; glutathione; site; microrna ... See more keywords
Quantitative Imaging of MicroRNA‐21 In Vivo for Real‐Time Monitoring of the Cancer Initiation and Progression
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202407348
Abstract: MicroRNA‐21 (MiR‐21) has been confirmed to be upregulated in tumors, and its abnormal expression is closely associated with tumor occurrence. However, the traditional imaging methods are limited to qualitative imaging of miR‐21, and no effective… read more here.
Keywords: cancer; initiation; initiation progression; cancer initiation ... See more keywords
Development of an Inhalable DNA Tetrahedron MicroRNA Sponge
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Materials"
DOI: 10.1002/adma.202414336
Abstract: In designing aerosolized drugs, the challenge lies in achieving optimal penetration and retention. Existing delivery systems prioritize larger particles for prolonged intrapulmonary retention, compromising penetration speed. Conversely, smaller nanoparticles face rapid clearance and limited retention.… read more here.
Keywords: development inhalable; retention; sponge; penetration ... See more keywords
Clinicopathological significance of microRNA‐21 in extracellular vesicles of pleural lavage fluid of lung adenocarcinoma and its functions inducing the mesothelial to mesenchymal transition
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Medicine"
DOI: 10.1002/cam4.2928
Abstract: Pre‐resection pleural lavage cytology is useful to predict tumor recurrence and the prognosis of lung cancer patients. Recently, extracellular vesicles (EVs) isolated from effusion specimens have come under the spotlight, and several studies showed that… read more here.
Keywords: extracellular vesicles; mesothelial mesenchymal; lavage; pleural lavage ... See more keywords
The microRNA‐1908 up‐regulation in the peripheral blood cells impairs amyloid clearance by targeting ApoE
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Geriatric Psychiatry"
DOI: 10.1002/gps.4881
Abstract: To give a new insight into the mechanism of ApoE dysregulation and microRNA‐1908 in Alzheimer's disease (AD). read more here.
Keywords: microrna 1908; peripheral blood; 1908 regulation; blood cells ... See more keywords
A strand displacement signal amplification-assisted fluorescence assay for sensitive detection of microRNA.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of separation science"
DOI: 10.1002/jssc.202300123
Abstract: MicroRNA is a vital biomarker because of its abnormal expression in the emergence and development of diseases, especially in cancers. Herein, a label-free fluorescent sensing platform is proposed for detecting microRNA-21, coupled with the cascade… read more here.
Keywords: signal amplification; amplification assisted; displacement signal; detection ... See more keywords
Functional high-throughput screening reveals miR-323a-5p and miR-342-5p as new tumor-suppressive microRNA for neuroblastoma
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-019-03041-4
Abstract: Current therapies for most non-infectious diseases are directed at or affect functionality of the human translated genome, barely 2% of all genetic information. By contrast, the therapeutic potential of targeting the transcriptome, ~ 70% of the… read more here.
Keywords: 323a mir; mir 323a; mir 342; tumor suppressive ... See more keywords
Circulating microRNA-30a-5p, microRNA-101-3p, microRNA-140-3p and microRNA-141-3p as potential biomarkers for dexmedetomidine response in pediatric patients.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of clinical pharmacology"
DOI: 10.1007/s00228-021-03178-x
Abstract: PURPOSE The aim of this study was to investigate the expression levels of plasma miR-30a-5p, miR-101-3p, miR-140-3p and miR-141-3p and their relationship to dexmedetomidine efficacy and adverse effects in pediatric patients. METHODS The expression levels… read more here.
Keywords: mir 101; mir; 101 mir; mir 30a ... See more keywords
Functional annotation of differentially expressed fetal cardiac microRNA targets: implication for microRNA-based cardiovascular therapeutics
Sign Up to like & getrecommendations! Published in 2018 at "3 Biotech"
DOI: 10.1007/s13205-018-1520-8
Abstract: Gene expression pattern of a failing heart depicts remarkable similarity with developing fetal heart. Elucidating genetic as well as epigenetic mechanisms regulating the gene expression during cardiac development will improve our understanding of cardiovascular diseases.… read more here.
Keywords: functional annotation; fetal cardiac; differentially expressed; gene ... See more keywords
Label-free and sensitive microRNA detection based on a target recycling amplification-integrated superlong poly(thymine)-hosted copper nanoparticle strategy.
Sign Up to like & getrecommendations! Published in 2018 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2018.01.010
Abstract: Poly(thymine)-hosted copper nanoparticles (poly T-CuNPs) have emerged as a promising label-free fluorophore for bioanalysis, but its application in RNA-related studies is still rarely explored. Herein, by utilizing duplex-specific nuclease (DSN) as a convertor to integrate… read more here.
Keywords: detection; superlong poly; target; label free ... See more keywords
Post-synthesis functionalized hydrogel microparticles for high performance microRNA detection.
Sign Up to like & getrecommendations! Published in 2019 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2019.05.009
Abstract: Encoded hydrogel microparticles, synthesized by Stop Flow Lithography (SFL), have shown great potential for microRNA assays for their capability to provide high multiplexing capacity and solution-like hybridization kinetics. However, due to the low conversion of… read more here.
Keywords: synthesis; performance; hydrogel microparticles; microrna ... See more keywords