Targeting microRNA-134 for seizure control and disease modification in epilepsy
Sign Up to like & getrecommendations! Published in 2019 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2019.07.008
Abstract: MicroRNA-134 is a brain-enriched small noncoding RNA that has been implicated in diverse neuronal functions, including regulating network excitability. Increased expression of microRNA-134 has been reported in several experimental epilepsy models and in resected brain… read more here.
Keywords: microrna 134; epilepsy; 134 seizure; disease ... See more keywords
Spared CA1 pyramidal neuron function and hippocampal performance following antisense knockdown of microRNA‐134
Sign Up to like & getrecommendations! Published in 2018 at "Epilepsia"
DOI: 10.1111/epi.14475
Abstract: Inhibition of microRNA‐134 by an oligonucleotide antagomir (ant‐134) has been shown to produce powerful antiseizure effects in multiple models of epilepsy. However, to successfully translate the treatment to the clinic, it is important to assess… read more here.
Keywords: microrna 134; spared ca1; ca1 pyramidal; function hippocampal ... See more keywords