microRNA-145 mediates xylosyltransferase-I induction in myofibroblasts via suppression of transcription factor KLF4.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.12.120
Abstract: Remodelling of the extracellular matrix by myofibroblasts is crucial for wound repair, but if deregulated, it might contribute to the development of fibrosis. Fibroblast-to-myofibroblast differentiation is promoted by aberrant microRNA-145-5p (miR-145) expression in response to… read more here.
Keywords: transcription; mir 145; microrna 145; expression ... See more keywords
Atorvastatin induces MicroRNA-145 expression in HEPG2 cells via regulation of the PI3K/AKT signalling pathway.
Sign Up to like & getrecommendations! Published in 2018 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2018.04.005
Abstract: The use of statins as a potential cancer drug has been investigated; however the molecular mechanisms involved in their anti-oxidant, anti-proliferative and anti-cancer effects remain elusive. In our study, we investigated the involvement of downstream… read more here.
Keywords: microrna 145; pi3k akt; expression hepg2; expression ... See more keywords
Long noncoding RNA H19 suppresses cardiac hypertrophy through the MicroRNA-145-3p/SMAD4 axis
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2021.2017564
Abstract: ABSTRACT Sustained cardiac hypertrophy (CH) contributes to many heart diseases. Long noncoding RNAs (lncRNAs) collectively play critical roles in cardiovascular diseases (CVDs). However, the roles of lncRNA H19 in CH are still unclear. A CH… read more here.
Keywords: long noncoding; cardiac hypertrophy; h19; smad4 ... See more keywords
MicroRNA‐145 regulates disabled‐2 and Wnt3a expression in cardiomyocytes under hyperglycaemia
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Clinical Investigation"
DOI: 10.1111/eci.12867
Abstract: MicroRNA‐145 (miR‐145) could protect cardiomyocyte apoptosis against oxidative stress and repair infarcted myocardium. Angiotensin II (Ang II), a pro‐inflammatory cytokine could modulate myocardial remodelling. However, the role of hyperglycaemia on miR‐145 expression in cardiomyocyte or… read more here.
Keywords: 145 regulates; mir 145; microrna 145; expression cardiomyocytes ... See more keywords
Knock‐out of MicroRNA 145 impairs cardiac fibroblast function and wound healing post‐myocardial infarction
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.15597
Abstract: Prevention of infarct scar thinning and dilatation and stimulation of scar contracture can prevent progressive heart failure. Since microRNA 145 (miR‐145) plays an important role in cardiac fibroblast response to wound healing and cardiac repair… read more here.
Keywords: function; cardiac fibroblast; microrna 145; mir 145 ... See more keywords
MicroRNA-145 inhibits the malignant phenotypes of gastric carcinoma cells via downregulation of fascin 1 expression
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2022.12613
Abstract: Following the publication of this paper, it was drawn to the Editors' attention by a concerned reader that certain of the cell apoptotic assay data shown in Figs. 3D and 4D were strikingly similar to data… read more here.
Keywords: molecular medicine; medicine; inhibits malignant; 145 inhibits ... See more keywords