microRNA‐27a and microRNA‐146a SNP in cerebral malaria
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.529
Abstract: During Plasmodium falciparum infection, microRNA expression alters in brain tissue of mice with cerebral malaria compared to noninfected controls. MicroRNA regulates gene expression post‐transcriptionally to influence biological processes. Cerebral malaria pathology caused mainly by the… read more here.
Keywords: 146a snp; 27a microrna; microrna 146a; microrna 27a ... See more keywords
Genetic variants of microRNA-146a gene: an indicator of systemic lupus erythematosus susceptibility, lupus nephritis, and disease activity.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular biology reports"
DOI: 10.1007/s11033-020-05802-y
Abstract: Genetic variations of microRNA encoding genes influence various sorts of diseases by modifying the expression or activity of microRNAs. MicroRNA 146a is an epigenetic regulator of immune response through controlling the type I interferon (IFN)… read more here.
Keywords: lupus; disease activity; microrna 146a; lupus nephritis ... See more keywords
MicroRNA‐146a protects against LPS‐induced organ damage by inhibiting Notch1 in macrophage
Sign Up to like & getrecommendations! Published in 2018 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2018.07.040
Abstract: &NA; MicroRNA‐146a is a well‐studied microRNA participating in immune and inflammatory diseases, but its role in sepsis has not been investigated. Here in our study, we found increased level of microRNA‐146a in macrophage stimulated by… read more here.
Keywords: notch1 macrophage; mir 146a; organ damage; microrna 146a ... See more keywords
MicroRNA-146a governs fibroblast activation and joint pathology in arthritis.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of autoimmunity"
DOI: 10.1016/j.jaut.2017.05.006
Abstract: Synovial fibroblasts are key cells orchestrating the inflammatory response in arthritis. Here we demonstrate that loss of miR-146a, a key epigenetic regulator of the innate immune response, leads to increased joint destruction in a TNF-driven… read more here.
Keywords: mir 146a; response; pathology; microrna 146a ... See more keywords
Investigation of the miRNA146a and miRNA155 gene expression levels in patients with multiple sclerosis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Neuroscience"
DOI: 10.1016/j.jocn.2020.04.071
Abstract: Multiple sclerosis (MS) is a chronic inflammatory disease and the most common neurodegenerative status. MicroRNAs play an important role in macrophage response to inflammatory processes, and alterations in miRNA levels trigger the inactivation of specific… read more here.
Keywords: microrna 155; microrna 146a; expression; 146a microrna ... See more keywords
First dual binder of microRNA-146a and monomeric tau: a novel approach for multitargeted therapeutics for neurodegenerative diseases.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical communications"
DOI: 10.1039/d0cc04249h
Abstract: We report a new approach for the development of multitargeted therapeutics for Alzheimer's disease (AD) based on dual targeting of monomeric tau and biogenesis of microRNA-146a. Compound MG-1102 displayed a superior neuroprotective activity, in comparison… read more here.
Keywords: first dual; monomeric tau; multitargeted therapeutics; microrna 146a ... See more keywords
Effects of microRNA-146a on the proliferation and apoptosis of human osteochondrocytes by targeting TRAF6 through the NF- κB signalling pathway
Sign Up to like & getrecommendations! Published in 2017 at "Bioscience Reports"
DOI: 10.1042/bsr20170180
Abstract: MicroRNAs are important cellular mediators of mRNA degradation and translation repression, which in turn can have an impact on various processes and, if their function is perturbed, can cause disease. Here, we summarize the recent… read more here.
Keywords: proliferation apoptosis; 146a proliferation; proliferation; microrna 146a ... See more keywords
02.46 Microrna-146a and disease activity in sle patients
Sign Up to like & getrecommendations! Published in 2017 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2016-211050.46
Abstract: Background Altered expression of microRNAs have been implicated in the pathogenesis of SLE due to their role in both the adaptive and innate immunity. Recent studies are trying to identify aberrant microRNA level as a… read more here.
Keywords: sle patients; disease activity; microrna 146a; mir 146a ... See more keywords
Mechanism of MicroRNA-146a/Notch2 Signaling Regulating IL-6 in Graves Ophthalmopathy
Sign Up to like & getrecommendations! Published in 2017 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000464430
Abstract: Background/Aims: We intended to investigate the significance of microRNA-146a, Notch2 and IL-6 on Graves ophthalmopathy (GO) and the relationships among them. Methods: About 27 GO patients were incorporated in this study, including 13 patients with… read more here.
Keywords: expression notch2; graves ophthalmopathy; mechanism microrna; 146a notch2 ... See more keywords