Estrogen inhibits osteoclasts formation and bone resorption via microRNA‐27a targeting PPARγ and APC
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26788
Abstract: Inhibition of osteoclasts formation and bone resorption by estrogen is very important in the etiology of postmenopausal osteoporosis. The mechanisms of this process are still not fully understood. Recent studies implicated an important role of… read more here.
Keywords: bone resorption; estrogen; bone; microrna 27a ... See more keywords
microRNA‐27a and microRNA‐146a SNP in cerebral malaria
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.529
Abstract: During Plasmodium falciparum infection, microRNA expression alters in brain tissue of mice with cerebral malaria compared to noninfected controls. MicroRNA regulates gene expression post‐transcriptionally to influence biological processes. Cerebral malaria pathology caused mainly by the… read more here.
Keywords: 146a snp; 27a microrna; microrna 146a; microrna 27a ... See more keywords
MicroRNA-27a, downregulated in human obesity, exerts an antiapoptotic function in adipocytes.
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DOI: 10.1507/endocrj.ej22-0288
Abstract: Adipocyte apoptosis is a key initial event that contributes to macrophage infiltration into adipose tissue (AT) and thus triggers AT inflammation in obesity. MicroRNA-27a (miR-27a) was shown to mediate the pathological processes of many metabolic… read more here.
Keywords: function adipocytes; apoptosis; antiapoptotic function; microrna 27a ... See more keywords
Knockdown of miR-27a sensitizes colorectal cancer stem cells to TRAIL by promoting the formation of Apaf-1-caspase-9 complex
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DOI: 10.18632/oncotarget.16779
Abstract: MicroRNAs have been proved to participate in multiple biological processes in cancers. For developing resistance to cytotoxic drug, cancer cells, especially the cancer stem cells, usually change their microRNA expression profile to survive in hostile… read more here.
Keywords: cancer stem; colorectal cancer; microrna 27a; cancer ... See more keywords